Results 51 to 60 of about 14,201,582 (335)

The pause-initiation limit restricts transcription activation in human cells.

, 2019
Eukaryotic gene transcription is often controlled at the level of RNA polymerase II (Pol II) pausing in the promoter-proximal region. Pausing Pol II limits the frequency of transcription initiation ('pause-initiation limit'), predicting that the pause ...
Cramer, P., Gressel, S., Schwalb, B.
core   +1 more source

Survival Outcomes and Complications Among Canadian Children With Retinoblastoma: A Population‐Based Report From CYP‐C

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Purpose Retinoblastoma (RB) is the most common pediatric ocular cancer, yet population‐based data on survival and risk factors remain limited. This study aimed to describe survival in a large national RB cohort and identify predictors of death and complications.
Samuel Sassine, Ofélie Trudeau‐Ferrin, Caroline Laverdière, Patrick Hamel, Rosanne Superstein, Bénédicte Koukoui, Carole Provost, Paul C. Nathan, Vijay Ramaswamy, Furqan Shaikh, Brenda Gallie, Ashwin Mallipatna, Stephanie Kletke, Helen Dimaras, Hallie Coltin   +14 more
wiley   +1 more source

Advancing pharmacogenomic research in US Hmong populations: prevalence of key single nucleotide variations in California Hmong

Frontiers in Pharmacology
IntroductionIn collaboration with the Minnesota Hmong community, we have previously discovered significant differences in allele frequencies for key Single Nucleotide Variations (SNVs) within Very Important Pharmacogenes (VIPs) between Hmong and East ...
Boguang Sun, Tou Thao, Kathleen Culhane-Pera, Eric Yang, Mai Yang Thor, Pao Yang, Metta Xiong, Zoua Vang, Robert J. Straka   +8 more
doaj   +1 more source

Improving the efficiency of homologous recombination by chemical and biological approaches in Yarrowia lipolytica. [PDF]

PLoS ONE, 2018
Gene targeting is a challenge in Yarrowia lipolytica (Y. lipolytica) where non-homologous end-joining (NHEJ) is predominant over homologous recombination (HR). To improve the frequency and efficiency of HR in Y.
In-Seung Jang, Byung Jo Yu, Ji Yeon Jang, Jonggeon Jegal, Ju Young Lee   +4 more
doaj   +1 more source

The diversity of a distributed genome in bacterial populations

, 2010
The distributed genome hypothesis states that the set of genes in a population of bacteria is distributed over all individuals that belong to the specific taxon. It implies that certain genes can be gained and lost from generation to generation.
Baumdicker, F., Hess, W. R., Pfaffelhuber, P.   +2 more
core   +1 more source

Personalized Selumetinib Dosing in Pediatric Neurofibromatosis Type 1: Insights From a Pilot Therapeutic Drug Monitoring Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács, Zoltán Köllő, Balázs Gellért Karvaly, Mahmoud Obeidat, Rita Nagy, Péter Hegyi, Brigitta Teutsch, Eszter Tuboly, Miklós Garami   +8 more
wiley   +1 more source

Occurrence of the Leucine-to-Phenylalanine knockdown Resistance (kdr) Mutation in Anopheles Arabiensis Populations in Tanzania, Detected by a Simplified High-Throughput SSOP-ELISA Method. [PDF]

, 2006
Molecular markers of insecticide resistance can provide sensitive indicators of resistance development in malaria vector populations. Monitoring of insecticide resistance in vector populations is an important component of current malaria control ...
Alifrangis, Michael, Drakeley, Chris, Kulkarni, Manisha A, Kweka, Eliningaya, Lyimo, Issa, Magesa, Stephen, Malima, Robert, Matowo, Johnson, Mosha, Frank W, Peter, Justin, Rau, Manfred E, Rowland, Mark, Salanti, Ali   +12 more
core   +3 more sources

Sirolimus for Extracranial Arteriovenous Malformations: A Scoping Review of the Evidence in Syndromic and Non‐Syndromic Cases

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Arteriovenous malformations (AVMs) are rare, high‐flow, vascular anomalies that can occur either sporadically or as part of a genetic syndrome. AVMs can progress with serious morbidity and even mortality if left unchecked. Sirolimus is an mTOR inhibitor that is effective in low‐flow vascular malformations; however, its role in AVMs is unclear.
Will Swansson, Ingrid Winship, Gary Hammerschlag, Laura Scardamaglia   +3 more
wiley   +1 more source

Study on Radio-Frequency Signal Gene Characteristics From the Perspective of Fractal Theory

IEEE Access, 2019
Radio frequency signal identification technology is a non-password authentication method based on the physical layer hardware of the device. This paper explores the feature extraction and recognition method based on the gene characteristics of the radio ...
Jingchao Li, Yulong Ying, Guang Duan, Chunlei Ji, Chen Sun   +4 more
doaj   +1 more source

Genetic pattern and penetrance of polycystic kidney disease in the Western region of Iraq [PDF]

مجلة جامعة الانبار للعلوم الصرفة, 2012
The aims of this study are to identify the genetic pattern, estimation of gene frequency, penterance, prevalence of PKD, and to furnish an appropriate plan for genetic counselling specific for these families under investigation.
Louay Mohammed Alani
doaj   +1 more source