Results 41 to 50 of about 19,163,396 (329)

Gamma frequency entrainment attenuates amyloid load and modifies microglia

Nature, 2016
Changes in gamma oscillations (20–50 Hz) have been observed in several neurological disorders. However, the relationship between gamma oscillations and cellular pathologies is unclear.
Hunter F. Iaccarino, Annabelle C. Singer, Anthony J. Martorell, A. Rudenko, Fan Gao, Tyler Z Gillingham, H. Mathys, Jinsoo Seo, Oleg Kritskiy, Fatema Abdurrob, Chinnakkaruppan Adaikkan, Rebecca G. Canter, Richard Rueda, E. Brown, E. Boyden, L. Tsai   +15 more
semanticscholar   +1 more source

Gene duplication and evolution in recurring polyploidization–diploidization cycles in plants

Genome Biology, 2019
The sharp increase of plant genome and transcriptome data provide valuable resources to investigate evolutionary consequences of gene duplication in a range of taxa, and unravel common principles underlying duplicate gene retention.
Xin Qiao, Qionghou Li, Hao Yin, Kai-Jie Qi, Leiting Li, Run-Ze Wang, Shaoling Zhang, A. Paterson   +7 more
semanticscholar   +1 more source

Frequency and Pattern of Worldwide Ocular Gene Therapy Clinical Trials up to 2022

, 2023
The purpose of this study is to describe worldwide gene therapy clinical trials aimed at treating ophthalmic disorders. Information regarding all worldwide clinical trials was collected through 15 different sources, including ClinicalTrials.gov.
Hossein Ameri, Niranjana Kesavamoorthy, Dara N. Bruce   +2 more
core   +1 more source

Frequency and mutational spectrum of PIK3CA gene mutations in breast cancer patients: Largest and first report from Lebanon [PDF]

, 2023
The PIK3CA pathway is one of the most frequently altered pathways in human cancers, especially in breast cancer with approximately 40% of HR+/HER2– advanced breast cancer cases exhibiting mutations in the PIK3CA gene. While the mutations can occur across
Georges Chahine, Nabil Chamseddine, Nabhan, Therese, Antoine Finianos, Finianos, Antoine, Nagi El Saghir, Ghazi Zaatari, Tfayli, Arafat Hussein, Assi, Hazem I., Chahine, Georges Y., Sally Temraz, Rami Mahfouz, Kattan, Joseph G., El-Hachem, Georges, Younes, Ahmad, Chamseddine, Ali, Mahfouz, Rami A.R., Temraz, Sally N., Zaatari, Ghazi S., Gerges, Dany Abi, Marwan Ghosn, Hamadeh, Lama N., Hazem Assi, Dany Abi Gerges, Joseph Kattan, Farhat, Fadi Sami, Kourié, Hampig Raphaël, Hampig Kourie, Lama Farhat, Hady Ghanem, Mohammad Haidar, Chamseddine, Nabil M., Hilal, Lamia, Lamia Hilal, Georges El Hachem, Lama N. Hamadeh, Ahmad Younes, Therese Nabhan, Ghosn, Marwan G., Ali Chamseddine, Arafat Tfayli, El-Saghir, Nagi S., Ghanem, Hady, Farhat, Lama, Nasr, Fadi L., Fadi Nasr, Fadi Farhat, Haidar, Mohamad B.   +47 more
core   +1 more source

Reporte de cuatro casos de pacientes con síndrome de Jarcho-Levin en el departamento de Antioquia, Colombia

Biomédica: revista del Instituto Nacional de Salud, 2009
El síndrome de Jarcho-Levin es una displasia esquelética con alteraciones en la morfogénesis vertebral y en la segmentación costal, que se manifiesta con hemivertebras, fusión vertebral o agenesia vertebral, y fusión costal.
Jorge Hernán Montoya, Olga Lucía Morales   +1 more
doaj   +1 more source

Tumor evolution of glioma intrinsic gene expression subtype associates with immunological changes in the microenvironment

Cancer Cell, 2017
Summary We leveraged IDH wild-type glioblastomas, derivative neurospheres, and single cell gene expression profiles to define three tumor-intrinsic transcriptional subtypes designated as proneural, mesenchymal, and classical.
Qianghu Wang, Baoli Hu, Xin Hu, Hoon Kim, M. Squatrito, L. Scarpace, A. deCarvalho, Sali Lyu, Pengping Li, Yan Li, F. Barthel, H. Cho, Yu-Hsi Lin, N. Satani, Emmanuel Martínez-Ledesma, Siyuan Zheng, Edward F. Chang, C. Sauvé, A. Olar, Zheng-Dao Lan, G. Finocchiaro, J. Phillips, M. Berger, Konrad Gabrusiewicz, Guo-Can Wang, E. Eskilsson, Jian Hu, T. Mikkelsen, R. DePinho, F. Muller, A. Heimberger, E. Sulman, D. Nam, R. Verhaak   +33 more
semanticscholar   +1 more source

Information encoded in gene-frequency trajectories

Biosystems, 2023
30 pages, 3 ...
Konstantinos Mavreas, David Waxman
openaire   +3 more sources

ANALYSES OF GENE FREQUENCIES OF MATES [PDF]

Genetics, 1973
ABSTRACT A genic analysis of variance of data on mate pairs for a codominant gene is developed. This analysis provides estimators of the correlation, F, of genes within individuals, of the correlation, Θ, of genes between mates, and of various variances-all relative to the correlation or variation among genes of nonmates.
openaire   +2 more sources

Construction of a droplet digital PCR detection system for platelet HPA-3 and HPA-15 genotyping

Zhongguo shuxue zazhi
Objective To establish a highly sensitive detection method of platelet HPA-3 and HPA-15 genotyping by droplet digital PCR (ddPCR), and to explore the feasibility of applying it to the detection of human platelet antigen (HPA) compatibility in maternal ...
Xiaojiao KONG, Hongmei WANG, Shengbao DUAN, Tiemei LIU   +3 more
doaj   +1 more source

UNCORRELATED RANDOM ENVIRONMENTS AND THEIR EFFECTS ON GENE FREQUENCY [PDF]

Evolution, 1974
In the previous paper (Cook and Hartl, 1974) we considered the distribution of gene frequencies in a population evolving in a fluctuating environment when the environmental changes were uncorrelated. In the present article we extend the theory to include autocorrelations in the environment. WVe consider three models. The first (denoted model III in the
R Dennis, Cook, Daniel L, Hartl
openaire   +4 more sources