Results 71 to 80 of about 1,747,624 (329)

Serological and RHD genotyping characteristics of RhD-negative populations in primary screening in Beijing

Zhongguo shuxue zazhi
Objective To study the RHD genotyping of primary screening RhD negative population in Beijing, and analyze the serological characteristics of different genotypes and the distribution of Rh phenotypes.
Ke SONG, Chunya MA, Yuanyuan LUO, Yang YU   +3 more
doaj   +1 more source

Determining the Frequency of Genes Producing Colicins Ia and V in Escherichia coli Strains Isolated from Clinical Samples of Medical Centers in Yazd City [PDF]

Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd, 2023
Introduction: Bacteriocins are peptides with antimicrobial properties. They are ribosomally synthesized and produced by both gram-positive and gram-negative bacteria. The bacteriocins produced by Escherichia coli are called colicins.
Habibollah Zare, Akram Astani, Mina Golban, Mahmood Vakili, Ahmad Mosadegh   +4 more
doaj  

Refining the NaV1.7 pharmacophore of a class of venom‐derived peptide inhibitors via a combination of in silico screening and rational engineering

FEBS Letters, EarlyView.
Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma, Jennifer R. Deuis, Xinying Jia, Theo Crawford, Sassan Rahnama, Eivind A. B. Undheim, Irina Vetter, Yanni K. ‐Y. Chin, Mehdi Mobli   +8 more
wiley   +1 more source

A dynamical model reveals gene co-localizations in nucleus [PDF]

, 2009
Co-localization of networks of genes in the nucleus is thought to play an important role in determining gene expression patterns. Based upon experimental data, we built a dynamical model to test whether pure diffusion could account for the observed co ...
Jing Kang, Bing Xu, Ye Yao, Wei Lin, Conor Hennessy, Peter Fraser, Jianfeng Feng, William Stafford Noble, C Osborne, L Chakalova, T Sexton, P Fraser, H Sutherland, PR Cook, S Schoenfelder, M Nicodemi, M Levine, F Markowetz, I Junier, F Kepes, T Misteli, I Rajapakse, D Sage, L Ashall, L Cai, A Papantonis, CS Osborne, DL Spector, SA Isaacsona, JR Chubb, G Natoli, X Darzacq, L Chakalova, S Gasser, P Heun, L Chakalova, N Geva-Zatorsky, C Chuang, M Dundr, M Doi, E Lieberman-Aiden, D Marenduzzo, S Oehler, S Kou, G Pavliotis, WL Lu, J Kang   +46 more
core   +5 more sources

The power of microRNA regulation—insights into immunity and metabolism

FEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto, Nicola Manfrini, Stefano Biffo   +2 more
wiley   +1 more source

Epigenetics as a mechanism driving polygenic clinical drug resistance [PDF]

, 2006
Aberrant methylation of CpG islands located at or near gene promoters is associated with inactivation of gene expression during tumour development.
A Balmain, AJ Boivin, B Hendrich, BC Richardson, C Anacleto, C Grunau, CA Eads, E Bair, E Papouli, EE Cameron, F Lyko, G Egger, G Gifford, G Strathdee, G Strathdee, HG Chang, J Hall, J M Teodoridis, J Tra, JA Plumb, JF Costello, JG Herman, JM Teodoridis, JM Teodoridis, JP Issa, K Yamashita, L Zhang, LA Loeb, M Daskalakis, M Esteller, M Esteller, M Esteller, M Lachner, M Toyota, ME Valk-Lingbeek, MF Paz, MF Paz, MM Gottesman, MS Soengas, NP Bhattacharyya, PJ Johnson, PM Warnecke, R Agarwal, R Brown, R Brown, R M Glasspool, S Fulda, SH Wei, SH Wei, SL Gerson, SM Taylor, SW Lowe, T Taniguchi, T Ushijima, TH Huang, W Fischle, Y Pommier, Z Xiong   +57 more
core   +2 more sources

Identification of novel small molecule inhibitors of ETS transcription factors

FEBS Letters, EarlyView.
ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla, Zary Forghany, Jin Ma, Johan G. Hollander, Ruta Nachane, Karoly Szuhai, Pancras C. W. Hogendoorn, Peter ten Dijke, Dipen Shah, David A. Baker   +9 more
wiley   +1 more source

FREQUENCY OF NRAS AND KRAS GENES IN NEWLY DIAGNOSED ACUTE MYELOID LEUKEMIA PATIENTS

Pakistan Armed Forces Medical Journal, 2020
Objective: To determine the frequency of NRAS and KRAS mutations in newly diagnosed acute myeloid leukemia patients and correlation with their clinicopathological parameters along with prognostic impact. Study Design: Cross-sectional study.
Sidra Barlas, Helen Mary Robert, Rafia Mahmood, Asad Mahmood, Ayesha Khurshid, Saleem Ahmed Khan   +5 more
doaj  

Apolipoproteins AI/B/E gene polymorphism and their plasma levels in patients with coronary artery disease in a tertiary care-center of Eastern India

Indian Heart Journal, 2013
Aim: The present study was designed to investigate whether the three-apolipoprotein (AI, B, E) gene polymorphisms were related to alter their plasma protein levels and hence associated to coronary artery disease (CAD). Methods: We determined distribution
Santanu Biswas, Pradip K. Ghoshal, Bhubaneswar Halder, Kajal Ganguly, Arup DasBiswas, Nripendranath Mandal   +5 more
doaj   +1 more source

The cytoskeletal control of B cell receptor and integrin signaling in normal B cells and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley   +1 more source