Results 231 to 240 of about 1,645,919 (262)

Gene loss, thermogenesis, and the origin of birds

Annals of the New York Academy of Sciences, 2013
Compared to related taxa, birds have exceptionally enlarged and diversified skeletal muscles, features that are closely associated with skeletal diversification and are commonly explained by a diversity of avian ecological niches and locomotion types. The thermogenic muscle hypothesis (TMH) for the origin of birds proposes that such muscle hyperplasia ...
Stuart A, Newman, Nadezhda V, Mezentseva, Alexander V, Badyaev   +2 more
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Prospects for Gene Therapy in Hearing Loss

Journal of Basic and Clinical Physiology and Pharmacology, 2003
Deafness is the most common form of sensory impairment in humans. Depending on the age of onset, hearing impairment can affect oral language acquisition, cognitive development and psychosocial development. Here, we cover the latest advances in gene therapy for alleviating or preventing hearing loss.
Karen B, Avraham, Yehoash, Raphael
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Gene therapy for hereditary hearing loss

Hearing Research
Gene therapy is a technique by which exogenous genetic material is introduced into target cells to treat or prevent diseases caused by genetic mutations. Hearing loss is the most common sensory disorder. Genetic factors contribute to approximately 50 % of all cases of profound hearing loss, and more than 150 independent genes have been reported as ...
Zeming Fu, Liping Zhao, Yingyuan Guo, Jingpu Yang   +3 more
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Microbial Genes in the Human Genome: Lateral Transfer or Gene Loss?

Science, 2001
The human genome was analyzed for evidence that genes had been laterally transferred into the genome from prokaryotic organisms. Protein sequence comparisons of the proteomes of human, fruit fly, nematode worm, yeast, mustard weed, eukaryotic parasites, and all completed prokaryote genomes were performed, and all genes shared between human and each of ...
S L, Salzberg, O, White, J, Peterson, J A, Eisen   +3 more
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Limitations of Pseudogenes in Identifying Gene Losses

2008
The loss of previously established genes has been proposed as a major force in evolutionary change. While the sequencing of many new species offers the opportunity to identify cases of gene loss, the best method to do this with is unclear. A number of methods to identify gene losses rely on the presence of a pseudogene for each loss.
James C. Costello, Mira V. Han, Matthew W. Hahn   +2 more
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Gene Losses in the Human Genome

Science, 2012
A comprehensive survey of the human genome reveals variations that disrupt protein-coding genes.
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The retinoblastoma gene in breast cancer: allele loss is not correlated with loss of gene protein expression.

Cancer research, 1992
The significance of the retinoblastoma gene (RB) in the development of human breast cancer remains unclear. In the present study, loss of heterozygosity (LOH) in RB was found in 26% of 90 informative primary breast tumors and was correlated to DNA nondiploidy, a high S-phase fraction, and LOH at chromosome 17p13.3.
A, Borg, Q X, Zhang, P, Alm, H, Olsson, G, Sellberg   +4 more
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Advances in gene therapy hold promise for treating hereditary hearing loss

Molecular Therapy, 2023
Yingzi He, Yilai Shu
exaly  

Point mutations of homologs as an adaptive solution to the gene loss

Journal of Genetics and Genomics, 2023
Xiaojing Zhao, Liye Zhang
exaly  

Turning gene loss into phenotypic gain

Nature Reviews Genetics, 2022
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