Results 1 to 10 of about 86,476 (288)

Timing of whole genome duplication is associated with tumor-specific MHC-II depletion in serous ovarian cancer [PDF]

Nature Communications
Whole genome duplication is frequently observed in cancer, and its prevalence in our prior analysis of end-stage, homologous recombination deficient high grade serous ovarian cancer (almost 80% of samples) supports the notion that whole genome ...
Nikki L. Burdett, Madelynne O. Willis, Ahwan Pandey, Laura Twomey, Sara Alaei, Australian Ovarian Cancer Study Group, David D. L. Bowtell, Elizabeth L. Christie   +7 more
doaj   +5 more sources

Evidence for an ancient whole genome duplication in the cycad lineage.

PLoS ONE, 2017
Contrary to the many whole genome duplication events recorded for angiosperms (flowering plants), whole genome duplications in gymnosperms (non-flowering seed plants) seem to be much rarer.
Danielle Roodt, Rolf Lohaus, Lieven Sterck, Riaan L Swanepoel, Yves Van de Peer, Eshchar Mizrachi   +5 more
doaj   +7 more sources

ADARp150 counteracts whole genome duplication. [PDF]

Nucleic Acids Res
Impaired control of the G1/S checkpoint allows initiation of DNA replication under non-permissive conditions. Unscheduled S-phase entry is associated with DNA replication stress, demanding for other checkpoints or cellular pathways to maintain ...
van Gemert F, Drakaki A, Lozano IM, de Groot D, Uiterkamp MS, Proost N, Lieftink C, van de Ven M, Beijersbergen RL, Jacobs H, Te Riele H.   +10 more
europepmc   +5 more sources

Effect of Whole-Genome Duplication on the Evolutionary Rescue of Sterile Hybrid Monkeyflowers [PDF]

Plant Communications, 2020
Hybridisation is a creative evolutionary force, increasing genomic diversity, and facilitating adaptation and even speciation. Hybrids often face significant challenges to become established, including reduced fertility arising from genomic ...
Sofie Meeus, Kristyna Semberova, Nico De Storme   +2 more
exaly   +2 more sources

Escape from preferential retention following repeated whole genome duplication in plants

Frontiers in Plant Science, 2012
The well supported gene dosage hypothesis predicts that genes encoding proteins engaged in dose-sensitive interactions cannot be reduced back to single copies once all interacting partners are simultaneously duplicated in a whole genome duplication.
James C Schnable, Xiaowu eWang, J. Chris Pires, Michael eFreeling   +3 more
doaj   +3 more sources

Ohno-miRNAs: miRNA pairs derived from whole-genome duplication. [PDF]

PLoS Computational Biology
Two rounds of whole-genome duplication (WGD) occurred about 500 million years ago and played a major role in the evolution of the vertebrate genomes. Human genes derived from WGD are called "ohnologs".
Leonardo Agasso, Ivan Molineris, Michele Caselle   +2 more
doaj   +2 more sources

Gene count from target sequence capture places three whole genome duplication events in Hibiscus L. (Malvaceae)

BMC Ecology and Evolution, 2021
Background The great diversity in plant genome size and chromosome number is partly due to polyploidization (i.e. genome doubling events). The differences in genome size and chromosome number among diploid plant species can be a window into the ...
J. S. Eriksson, C. D. Bacon, D. J. Bennett, B. E. Pfeil, B. Oxelman, A. Antonelli   +5 more
doaj   +2 more sources

Does hybridization between divergent progenitors drive whole‐genome duplication?

Molecular Ecology, 2009
This is the peer reviewed version of the following article: BUGGS, R. J. A., SOLTIS, P. S. and SOLTIS, D. E. (2009), Does hybridization between divergent progenitors drive whole-genome duplication?.
Richard J A Buggs, Pamela S Soltis, Douglas E Soltis   +2 more
exaly   +2 more sources

Cell Type Resolved Expression of Duplicate Genes Retained From Whole Genome Duplication in Atlantic salmon. [PDF]

Genome Biol Evol
The functional and evolutionary outcomes of whole genome duplication (WGD) events are driven by global remodelling of gene expression. Most investigations of gene expression changes following WGD have applied bulk transcriptomics using tissue samples ...
Taylor RS, Ruiz Daniels R, Macqueen DJ.
europepmc   +2 more sources

An atlas of fish genome evolution reveals delayed rediploidization following the teleost whole-genome duplication [PDF]

, 2022
International audienceTeleost fishes are ancient tetraploids stemming from an ancestral whole-genome duplication that may have contributed to the impressive diversification of this clade.
Guiguen, Yann, Louis, Alexandra, Montfort, Jérôme, Yann Guiguen, Hugues Roest Crollius, Camille Berthelot, Roest Crollius, Hugues, Crollius, Hugues, Roest, Jérôme Montfort, Parey, Elise, Alexandra Louis, Elise Parey, Berthelot, Camille   +12 more
core   +2 more sources