Results 41 to 50 of about 2,879,199 (292)

Homozygous duplication identified by whole genome sequencing causes LRBA deficiency

npj Genomic Medicine, 2021
In more than one-third of primary immunodeficiency (PID) patients, extensive genetic analysis including whole-exome sequencing (WES) fails to identify the genetic defect.
Daniele Merico, Yehonatan Pasternak, Mehdi Zarrei, Edward J. Higginbotham, Bhooma Thiruvahindrapuram, Ori Scott, Jessica Willett-Pachul, Eyal Grunebaum, Julia Upton, Adelle Atkinson, Vy H. D. Kim, Elbay Aliyev, Khalid Fakhro, Stephen W. Scherer, Chaim M. Roifman   +14 more
doaj   +1 more source

Whole genome duplications and the diversification of the Globin-X genes of vertebrates [PDF]

Genome Biology and Evolution, 2021
Abstract The globin superfamily of vertebrate genes is a textbook example of how the interplay between local gene duplications, whole-genome duplications, and regulatory changes can facilitate the evolution of novel protein functions.
Federico G. Hoffmann, Jay F. Storz, Shigehiro Kuraku, Mike W. Vandewege, Juan C. Opazo   +4 more
openaire   +3 more sources

Whole genome duplication and transposable element proliferation drive genome expansion in Corydoradinae catfishes [PDF]

, 2018
Genome size varies significantly across eukaryotic taxa and the largest changes are typically driven by macro-mutations such as whole genome duplications (WGDs) and proliferation of repetitive elements.
Simon Creer, Taylor, Martin I, Sarah Marburger, Martin I. Taylor, Alexandrou, Markos A., Alexandrou, Markos A, Oliveira, Claudio [UNESP], Claudio Oliveira, Markos A. Alexandrou, Taggart, John B, Gary Carvalho, Marburger, Sarah, Oliveira, Claudio, Carvalho, Gary, Taggart, John B., Taylor, Martin I., Creer, Simon, Alexandrou, Markos, John B. Taggart   +18 more
core   +1 more source

Genome-Wide Identification and Evolutionary Analysis of AOMT Gene Family in Pomegranate (Punica granatum)

Agronomy, 2021
Gene duplication is the major resource with which to generate new genes, which provide raw material for novel functions evolution. Thus, to elucidate the gene family evolution after duplication events is of vital importance.
Xinhui Zhang, Weicheng Yuan, Yujie Zhao, Yuan Ren, Xueqing Zhao, Zhaohe Yuan   +5 more
doaj   +1 more source

Pervasive genome duplications across the plant tree of life and their links to major evolutionary innovations and transitions

Computational and Structural Biotechnology Journal, 2022
Whole-genome duplication (WGD) has occurred repeatedly during plant evolution and diversification, providing genetic layers for evolving new functions and phenotypes.
Xin Qiao, Shaoling Zhang, Andrew H. Paterson   +2 more
doaj   +1 more source

Functional divergence of gene duplicates – a domain-centric view

BMC Evolutionary Biology, 2012
Background Gene duplicates have been shown to evolve at different rates. Here we further investigate the mechanism and functional underpinning of this phenomenon by assessing asymmetric evolution specifically within functional domains of gene duplicates.
Khaladkar Mugdha, Hannenhalli Sridhar
doaj   +1 more source

Autopolyploidy genome duplication preserves other ancient genome duplications in Atlantic salmon (Salmo salar). [PDF]

PLoS ONE, 2017
Salmonids (e.g. Atlantic salmon, Pacific salmon, and trouts) have a long legacy of genome duplication. In addition to three ancient genome duplications that all teleosts are thought to share, salmonids have had one additional genome duplication.
Kris A Christensen, William S Davidson
doaj   +1 more source

Molecular Dating of the Teleost Whole Genome Duplication (3R) Is Compatible With the Expectations of Delayed Rediploidization [PDF]

Genome Biology and Evolution
Minbo Qi, Edmund R R Moody, Davide Pisani   +2 more
exaly   +2 more sources

Universal Features in the Genome-level Evolution of Protein Domains [PDF]

, 2008
Protein domains are found on genomes with notable statistical distributions, which bear a high degree of similarity. Previous work has shown how these distributions can be accounted for by simple models, where the main ingredients are probabilities of ...
Bruno Bassetti, Alessandro L. Sellerio, Philip D. Heijning, Marco Cosentino Lagomarsino, M. Cosentino Lagomarsino, B.F. Bassetti, P. D. Heijning, A. L. Sellerio   +7 more
core   +1 more source

High-quality reference genome sequences of two Cannaceae species provide insights into the evolution of Cannaceae

Frontiers in Plant Science, 2022
Canna edulis Ker-Gawl and Canna indica L. are species belonging to the Cannaceae family and both have a very high economic value. Here, we aimed to assemble genomes of C. edulis and C. indica at the chromosome level to generate a reference genome for the
Yuhua Fu, Sirong Jiang, Sirong Jiang, Meiling Zou, Meiling Zou, Jianjia Xiao, Jianjia Xiao, Long Yang, Chunfang Luo, Ping Rao, Wenquan Wang, Zhengui Ou, Fanzhi Liu, Zhiqiang Xia, Zhiqiang Xia   +14 more
doaj   +1 more source