Spatial Transcriptomics Analysis of Spatially Dense Gene Expression Prediction [PDF]
arXivSpatial transcriptomics (ST) measures gene expression at fine-grained spatial resolution, offering insights into tissue molecular landscapes. Previous methods for spatial gene expression prediction usually crop spots of interest from pathology tissue slide images, and learn a model that maps each spot to a single gene expression profile.
arxiv
Molecular Oncology, EarlyView.In this explorative biomarker analysis, we assessed serial sampling of circulating tumor cells (CTCs) with CellSearch in two randomized trials testing immune checkpoint inhibitors (ICIs) in metastatic breast cancer. Our data demonstrate a prognostic potential of CTCs, most apparent 4 weeks into ICI therapy.
Nikolai Kragøe Andresen +13 more
wiley +1 more source
Ir-genes in H-2 regulate generation of anti-viral cytotoxic T cells. Mapping to K or D and dominance of unresponsiveness. [PDF]
, 1978 Rolf M. Zinkernagel +9 more
openalex +1 more source
Characterization and Gene Mapping of an Open-Glume Oryza sativa L. Mutant. [PDF]
Int J Mol Sci, 2023 Mao X, Zheng X, Chen W, Li C.
europepmc +1 more source
Correlation via synthesis: end-to-end nodule image generation and radiogenomic map learning based on generative adversarial network [PDF]
arXiv, 2019 Radiogenomic map linking image features and gene expression profiles is useful for noninvasively identifying molecular properties of a particular type of disease. Conventionally, such map is produced in three separate steps: 1) gene-clustering to "metagenes", 2) image feature extraction, and 3) statistical correlation between metagenes and image ...
arxiv
Cell‐free and extracellular vesicle microRNAs with clinical utility for solid tumors
Molecular Oncology, EarlyView.Cell‐free microRNAs (cfmiRs) are small‐RNA circulating molecules detectable in almost all body biofluids. Innovative technologies have improved the application of cfmiRs to oncology, with a focus on clinical needs for different solid tumors, but with emphasis on diagnosis, prognosis, cancer recurrence, as well as treatment monitoring.
Yoshinori Hayashi +6 more
wiley +1 more source
Genetic mapping of xthA, the structural gene for exonuclease III in Escherichia coli K-12 [PDF]
, 1976 Bradley J. White +3 more
openalex +1 more source
Molecular insights into the mechanisms of a leaf color mutant in Anoectochilus roxburghii by gene mapping and transcriptome profiling based on PacBio Sequel II. [PDF]
Sci Rep, 2023 Huang H, Zou H, Lin H, Dai Y, Lin J.
europepmc +1 more source
Roadblocked monotonic paths and the enumeration of coalescent histories for non-matching caterpillar gene trees and species trees [PDF]
arXiv, 2019 Given a gene tree topology and a species tree topology, a coalescent history represents a possible mapping of the list of gene tree coalescences to associated branches of a species tree on which those coalescences take place. Enumerative properties of coalescent histories have been of interest in the analysis of relationships between gene trees and ...
arxiv
Molecular Oncology, EarlyView.The LEXOVE prospective study evaluated plasma cell‐free extracellular vesicle (cfEV) dynamics using Bradford assay and dynamic light scattering in metastatic non‐small cell lung cancer patients undergoing first‐line treatments, correlating a ∆cfEV < 20% with improved median progression‐free survival in responders versus non‐responders.
Valerio Gristina +17 more
wiley +1 more source