Results 81 to 90 of about 509,658 (266)
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Identification and Utilization of the Soybean Plant Height Locus PH19-31
AgronomyPlant height is a key agronomic trait in soybeans, directly influencing yield potential and agronomic performance. In this study, the tall-stem cultivar Heinong 63 and the dwarf-stem cultivar Longken 3077, along with their F2 populations, were used as ...
Manqing Ling +7 more
doaj +1 more source
Mapping RYR1, PIT1 and PRKAG3 using a commercial porcine population as a reference
浙江大学学报. 农业与生命科学版, 2005 Using a commercial porcine population produced by crossing of five swine breeds including Hampshire and Pietrain as a reference, three genes—RYR1, PIT1 and PRKAG3, which were located on chromosome 6, 13 and 15, respectively, were mapped by the method of ...
GUO Xiao-ling +3 more
doaj +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Genetic mapping and molecular marker development for white flesh color in tomato
Frontiers in Plant ScienceIntroductionFruit color significantly influences the quality of horticultural crops, which affects phytochemical diversity and consumer preferences.
Jie Liu +22 more
doaj +1 more source
Gene mapping and candidate gene analysis of multi-floret spikelet 3 (mfs3) in rice (Oryza sativa L.)
Journal of Integrative Agriculture, 2019 Rice (Oryza sativa L.) is one of the most important food crops worldwide and a model monocot plant for gene function analysis, so it is an ideal system for studying flower development.
Hao ZHENG +10 more
doaj +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source