Results 171 to 180 of about 600,813 (339)

MET variants with activating N‐lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation

Molecular Oncology, EarlyView.
MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin, Audrey Vinchent, Marie Fernandes, Isabelle Damour, Agathe Laratte, Rémi Tellier, Gabriella O. Estevam, Jean‐Pascal Meneboo, Céline Villenet, Clotilde Descarpentries, James S. Fraser, Martin Figeac, Alexis B. Cortot, Etienne Rouleau, David Tulasne   +14 more
wiley   +1 more source

Mapping of Progressive Necrosis Genes, Ne1 and Ne2 of Common Wheat by the Telocentric Method

, 1974
K. Nishikawa, Takashi Mori, Naomi TAKAMI, Yoshihiko Furuta   +3 more
openalex   +2 more sources

Chromosomal mapping of the simian sarcoma virus onc gene analogue in human cells. [PDF]

, 1982
Daniel Swan, O. Wesley McBride, Keith C. Robbins, D Keithley, E. Premkumar Reddy, Stuart A. Aaronson   +5 more
openalex   +1 more source

Complete genomic sequence and analysis of β2 toxin gene mapping of Clostridium perfringens JXJA17 isolated from piglets in China. [PDF]

Sci Rep, 2021
Zeng X, Liu B, Zhou J, Dai Y, Han C, Wang L, Wu Y, Zhang J.   +7 more
europepmc   +1 more source

Etoposide‐induced cancer cell death: roles of mitochondrial VDAC1 and calpain, and resistance mechanisms

Molecular Oncology, EarlyView.
The complex mode of action of the topoisomerase II inhibitor etoposide in triggering apoptosis involves several mechanisms: overexpression of the mitochondrial protein VDAC1, leading to its oligomerization and formation of a large channel that mediates the release of pro‐apoptotic protein; and overexpression of the apoptosis regulators p53, Bax, and ...
Aditya Karunanithi Nivedita, Varda Shoshan‐Barmatz   +1 more
wiley   +1 more source

Mapping of the Pneumococcus Chromosome. Linkage between the Genes Conferring Resistances to Erythromycin and Tetracycline and Its Implication to the Replication of the Chromosome

, 1973
L. O. Butler, G. Nicholas
openalex   +1 more source

Cloning and mapping of the manganese superoxide dismutase gene (sodA) of Escherichia coli K-12 [PDF]

, 1983
D Touati
openalex   +1 more source

Author Correction: Candidate gene mapping identifies genomic variations in the fire blight susceptibility genes HIPM and DIPM across the Malus germplasm. [PDF]

Sci Rep, 2021
Tegtmeier R, Pompili V, Singh J, Micheletti D, Silva KJP, Malnoy M, Khan A.   +6 more
europepmc   +1 more source

Respiratory complex I‐mediated NAD+ regeneration regulates cancer cell proliferation through the transcriptional and translational control of p21Cip1 expression by SIRT3 and SIRT7

Molecular Oncology, EarlyView.
NAD+ regeneration by mitochondrial complex I NADH dehydrogenase is important for cancer cell proliferation. Specifically, NAD+ is necessary for the activities of NAD+‐dependent deacetylases SIRT3 and SIRT7, which suppress the expression of p21Cip1 cyclin‐dependent kinase inhibitor, an antiproliferative molecule, at the translational and transcriptional
Masato Higurashi, Kazunori Mori, Hidetsugu Nakagawa, Momoko Uchida, Fumihiro Ishikawa, Motoko Shibanuma   +5 more
wiley   +1 more source

Mapping of the influenza virus genome: identification of the hemagglutinin and the neuraminidase genes.

, 1976
Peter Palese, Jerome L. Schulman
openalex   +1 more source