Results 191 to 200 of about 542,125 (315)

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Gene mapping and candidate gene analysis of a sorghum sheathed panicle-I mutant. [PDF]

Plant Genome
Ao J, Wang R, Li W, Ding Y, Xu J, Cao N, Gao X, Cheng B, Zhao D, Zhang L.   +9 more
europepmc   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Identification of the gene for Nance-Horan syndrome (NHS)

, 2004
Objective: To identify the gene or genes responsible for these diseases. Methods: Families with NHS were ascertained. The refined locus for CXN was used to focus the search for candidate genes, which were screened by polymerase chain reaction and ...
Brooks, S.P., Moore, A.T., Lehmann, O.J., Hardcastle, A.J., Poopalasundaram, S., Ebenezer, N.D.   +5 more
core  

Gene Mapping and Molecular Marker Development for Controlling Purple-Leaf Trait in Pakchoi (Brassica rapa subsp. chinensis (L.) Hanelt). [PDF]

Genes (Basel)
Song B, Yang Q, Zhang W, Yang X, Zhang L, Ouyang L, He L, Chen L, Jing Z, Huang T, Xu H, Li Y, Yang Q.   +12 more
europepmc   +1 more source

Gene mapping and functional annotation of GWAS of oral ulcers using FUMA software. [PDF]

Sci Rep, 2020
Jin X, Wang Y, Zhang X, Zhang W, Wang H, Chen C.   +5 more
europepmc   +1 more source

Using Breeding Populations With a Dual Purpose: Cultivar Development and Gene Mapping-A Case Study Using Resistance to Common Bacterial Blight in Dry Bean (Phaseolus vulgaris L.). [PDF]

Front Plant Sci, 2021
Simons KJ, Oladzad A, Lamppa R, Maniruzzaman, McClean PE, Osorno JM, Pasche JS.   +6 more
europepmc   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

IDENTIFICATION OF DISEASE GENES FOR RARE AUTOSOMAL RECESSIVE EPILEPTIC SYNDROMES BY HOMOZYGOSITY MAPPING

, 2011
Introduction: The genetics of the most common neurological disorders, including epilepsy, with mendelian inheritance has been dissected in the last twenty years. However the genetic etiology of some rare epileptic conditions is still unknown.
Coppola, Antonietta
core  

Gene mapping and identification of candidate genes controlling carotenoid accumulation of yellow kernels in foxtail millet. [PDF]

BMC Plant Biol
Wang J, Ma Q, Zhang Y, Duan Q, Zhen X, Zhang Y, Li H, Han Y, Zhang B.   +8 more
europepmc   +1 more source