Results 261 to 270 of about 1,866,513 (309)

Escherichia coli mutator genes

Trends in Microbiology, 1999
The isolation and characterization of Escherichia coli mutator genes have led to a better understanding of DNA replication fidelity mechanisms and to the discovery of important DNA repair pathways and their relationship to spontaneous mutagenesis. Mutator strains in a population of cells can be beneficial in that they allow rapid selection of variants ...
Horst, Jens-Peter, Wu, Te-hui, Marinus, Martin G.   +2 more
openaire   +3 more sources

Gene Mutation in Neonatal Jaundice – Mutations in UGT1A1 and OATP2 Genes

The Indian Journal of Pediatrics, 2016
This study evaluated the correlation of UGT1A1, OATP2 gene mutations and hyperbilirubinemia in newborns in Northern China. Gene mutations were analyzed at the 211 locus of UGT1A1 (Gly71Arg) and 388 locus of OATP2 (Asn130Asp). The 226 enrolled infants were divided into high, moderate, and low risk subgroups according to American Academy of Pediatrics ...
Jiang, Min, Luo, Jie, Yang, Caiyun, Lin, Ying, Yang, Xuefang   +4 more
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CARD15 gene mutations in periodontitis

Journal of Clinical Periodontology, 2004
AbstractObjectives: The CARD15 gene encodes the Nod2 protein, which is involved in intracellular recognition of bacterial products like peptidoglycan, activates inflammation and regulates apoptosis through nuclear factor‐kappa B, a transcription factor that plays a central role in the innate immunity. Two functional mutations, an insertion mutation at
Laine, M.L., Murillo, L.S., Morré, S.A., Winkel, E.G., Pena, A.S., van Winkelhoff, A.J.   +5 more
openaire   +4 more sources

Gene mutations in myelodysplasia

Leukemia Research, 1992
The myelodysplastic syndrome is a paradigm of human preleukaemia. Normal haemopoiesis is progressively displaced by an abnormal clone derived from a mutated stem cell. The initial mutation is unknown but its occurrence may be related to the overall load of random mutations which are a consequence of both intrinsic DNA defects and external mutagens ...
openaire   +2 more sources

Gene Mutations

2013
This chapter highlights gene mutations, which are heritable changes in the information encoded by a gene. Mutations create genetic variation and produce heritable changes in the genetic information. Generally, mutations have a detrimental effect. Mutations may be spontaneous or induced by mutagens in the environment. If mutations occur in somatic cells,
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Muscling out gene mutations

Science Translational Medicine, 2016
An adenovirus system that delivers gene-editing components rescues dystrophin expression in Duchenne muscular dystrophy muscle cells.
openaire   +2 more sources

Gene Mutation

Neuromuscular Disorders, 2001
openaire   +2 more sources

Mitochondrial encephalomyopathies: Gene mutation

Neuromuscular Disorders, 1994
  +7 more sources