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Journal of Computational Biology, 2018
Identification of gene regulatory networks (GRNs) is a fundamental step to understand the molecular role of each gene and it helps to develop treatment and cure of a disease. To identify GRNs, time-course gene expression data are widely used. However, the identification is hampered by intrinsic attributes of the data such as small sample size, a large ...
Jeonifer M. Garren, Jaejik Kim
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Identification of gene regulatory networks (GRNs) is a fundamental step to understand the molecular role of each gene and it helps to develop treatment and cure of a disease. To identify GRNs, time-course gene expression data are widely used. However, the identification is hampered by intrinsic attributes of the data such as small sample size, a large ...
Jeonifer M. Garren, Jaejik Kim
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Gene Regulatory Networks from Gene Ontology
2013Gene Ontology (GO) provides a controlled vocabulary and hierarchy of terms to facilitate the annotation of gene functions and molecular attributes. Given a set of genes, a Gene Ontology Network (GON) can be constructed from the corresponding GO annotations and semantic relations among GO terms.
Wenting Liu +5 more
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Gene function, gene networks and the fate of duplicated genes
Seminars in Cell & Developmental Biology, 1999For both copies of a duplicated gene to become fixed in a population and subsequently maintained, selection must favour individuals with both genes over individuals with one. Here I review and assess some of the proposed ways that gene structure and function might affect the likelihood of both copies acquiring distinct functions and therefore positive ...
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A network model for gene regulation
Computers & Chemical Engineering, 2007Advances in microarray technology have resulted in an exponential rise in gene expression data. Partially as a result of this, full genome sequences have been reported for many organisms. In addition several methods have been developed (a) for assigning functionality to previously unknown genes and (b) for measuring the output (i.e. gene expression) of
Rishi R. Gupta, Luke E. K. Achenie
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Gene networks in neurodegenerative disorders
Life Sciences, 2017Three neurodegenerative diseases [Amyotrophic Lateral Sclerosis (ALS), Parkinson's disease (PD) and Alzheimer's disease (AD)] have many characteristics like pathological mechanisms and genes. In this sense some researchers postulate that these diseases share the same alterations and that one alteration in a specific protein triggers one of these ...
Daniela, Recabarren, Marcelo, Alarcón
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Analog synthetic gene networks
Proceedings of the 3rd ACM International Conference on Nanoscale Computing and Communication, 2016In analog synthetic biology, the underlying mathematical principles of various biological processes is harnessed to perform complex computation. Here, we review key synthetic gene circuits that implement analog computation in living cells and propose biological constructs that can implement further novel analog computation.
Samuel David Perli, Timothy K. Lu
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2002
Abstract So far we have outlined the cellular composition of the nervous system, the spatial relationships of its basic. parts, and the network arrangement of its four basic functional systems. This is classical neuroscience. Like any organ the brain has a regional architecture and a number of functional systems, in this case motor ...
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Abstract So far we have outlined the cellular composition of the nervous system, the spatial relationships of its basic. parts, and the network arrangement of its four basic functional systems. This is classical neuroscience. Like any organ the brain has a regional architecture and a number of functional systems, in this case motor ...
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Mammalian Synthetic Gene Networks
Proceedings of the 25th edition on Great Lakes Symposium on VLSI, 2015Synthetic gene networks enable the programming of living cells to perform novel behaviors. Mammalian synthetic gene networks have largely been used as research tools to probe cellular function and more recently to engineer therapeutic capabilities. To create these networks researchers have developed a vast array of DNA -encoded parts that can serve as ...
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Development gene networks and evolution
Journal of Structural and Functional Genomics, 2003Animal development relies on complex programs of gene regulation that are likely to account for a significant fraction of the information carried in genomes. The evolution of these regulatory programs is a major contributor to the diversity of animal forms, yet the architecture of the transcriptional networks that comprise developmental programs is ...
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