Results 61 to 70 of about 347,215 (296)
Quality of computationally inferred gene ontology annotations. [PDF]
PLoS Computational Biology, 2012 Gene Ontology (GO) has established itself as the undisputed standard for protein function annotation. Most annotations are inferred electronically, i.e. without individual curator supervision, but they are widely considered unreliable.
Nives Skunca +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
Evaluation of high-throughput functional categorization of human disease genes
BMC Bioinformatics, 2007 Background Biological data that are well-organized by an ontology, such as Gene Ontology, enables high-throughput availability of the semantic web. It can also be used to facilitate high throughput classification of biomedical information.
Li Jianrong +4 more
doaj +1 more source
Gene Ontology (GO) Annotation in Biomedical Literature [PDF]
, 2008 In this paper, we propose an approach for doing Gene Ontology (GO) annotation on biomedical texts. The GO is an effort to create a controlled terminology for labelling gene functions in a more precise.
Gálvez, Carmen
core
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Applied Sciences, 2017 Microarray is a general scheme to identify differentially expressed genes for a target concept and can be used for biology. The output is presented utilizing a heatmap that biologists analyze in related terms of gene ontology to determine the ...
Somyung Oh +3 more
doaj +1 more source
Gene Ontology Meta Annotator for Plants (GOMAP)
Plant Methods, 2021 Annotating gene structures and functions to genome assemblies is necessary to make assembly resources useful for biological inference. Gene Ontology (GO) term assignment is the most used functional annotation system, and new methods for GO assignment ...
Kokulapalan Wimalanathan +1 more
doaj +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Improvements to cardiovascular Gene Ontology
Atherosclerosis, 2009 Gene Ontology (GO) provides a controlled vocabulary to describe the attributes of genes and gene products in any organism. Although one might initially wonder what relevance a 'controlled vocabulary' might have for cardiovascular science, such a resource is proving highly useful for researchers investigating complex cardiovascular disease phenotypes as
Lovering, Ruth C. +2 more
openaire +2 more sources
Comparing Relational and Ontological Triple Stores in Healthcare Domain
Entropy, 2017 Today’s technological improvements have made ubiquitous healthcare systems that converge into smart healthcare applications in order to solve patients’ problems, to communicate effectively with patients, and to improve healthcare service quality.
Ozgu Can +3 more
doaj +1 more source