Results 61 to 70 of about 463,290 (301)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

The Plant Ontology: A common reference ontology for plants [PDF]

, 2010
The Plant Ontology (PO) (http://www.plantontology.org) (Jaiswal et al., 2005; Avraham et al., 2008) was designed to facilitate cross-database querying and to foster consistent use of plant-specific terminology in annotation.
Chris, Mungall, Cooper Laurel, D., Gandolfo Maria, A., Justin, Elser, Pankaj, Jaiswal, Smith, Barry, Stevenson Dennis, W., Walls Ramona, L.   +7 more
core  

WormBase: a comprehensive resource for nematode research [PDF]

, 2009
WormBase (http://www.wormbase.org) is a central data repository for nematode biology. Initially created as a service to the Caenorhabditis elegans research field, WormBase has evolved into a powerful research tool in its own right.
Antoshechkin, Igor, Bieri, Tamberlyn, Blasiar, Darin, Chan, Juancarlos, Chen, Wen J., Davis, Paul, De La Cruz, Norie, Duesbury, Margaret, Durbin, Richard, Fang, Ruihua, Fernandes, Jolene, Han, Michael, Harris, Todd W., Kishore, Ranjana, Lee, Raymond, Müller, Hans-Michael, Nakamura, Cecilia, Ozersky, Philip, Petcherski, Andrei, Rangarajan, Arun, Rogers, Anthony, Schindelman, Gary, Schwarz, Erich M., Spieth, John, Stein, Lincoln D., Sternberg, Paul W., Tuli, Mary Ann, Van Auken, Kimberly, Wang, Daniel, Wang, Xiaodong, Williams, Gary, Yook, Karen   +31 more
core   +4 more sources

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Representing kidney development using the gene ontology. [PDF]

PLoS ONE, 2014
Gene Ontology (GO) provides dynamic controlled vocabularies to aid in the description of the functional biological attributes and subcellular locations of gene products from all taxonomic groups (www.geneontology.org).
Yasmin Alam-Faruque, David P Hill, Emily C Dimmer, Midori A Harris, Rebecca E Foulger, Susan Tweedie, Helen Attrill, Douglas G Howe, Stephen Randall Thomas, Duncan Davidson, Adrian S Woolf, Judith A Blake, Christopher J Mungall, Claire O'Donovan, Rolf Apweiler, Rachael P Huntley   +15 more
doaj   +1 more source

The Gene Ontology in 2010: extensions and refinements [PDF]

, 2010
The Gene Ontology (GO) Consortium (http://www.geneontology.org) (GOC) continues to develop, maintain and use a set of structured, controlled vocabularies for the annotation of genes, gene products and sequences.
Berardini, Tanya Z., Khodiyar, Varsha K., Lovering, Ruth C., Talmud, Philippa   +3 more
core  

The Plant Ontology facilitates comparisons of plant development stages across species [PDF]

, 2019
The Plant Ontology (PO) is a community resource consisting of standardized terms, definitions, and logical relations describing plant structures and development stages, augmented by a large database of annotations from genomic and phenomic studies.
Cooper, Laurel, Elser, Justin Lee, Gandolfo, Maria Alejandra, Jaiswal, Pankaj, Mungall, Christopher J., Smith, Barry, Stevenson, Dennis William, Walls, Ramona Lynn   +7 more
core   +2 more sources

Gene Ontology: Pitfalls, Biases, and Remedies [PDF]

, 2016
The Gene Ontology (GO) is a formidable resource but there are several considerations about it that are essential to understand the data and interpret it correctly. The GO is sufficiently simple that it can be used without deep understanding of its structure or how it is developed, which is both a strength and a weakness.
Gaudet, P, Dessimoz, C
openaire   +5 more sources

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Quality of computationally inferred gene ontology annotations. [PDF]

PLoS Computational Biology, 2012
Gene Ontology (GO) has established itself as the undisputed standard for protein function annotation. Most annotations are inferred electronically, i.e. without individual curator supervision, but they are widely considered unreliable.
Nives Skunca, Adrian Altenhoff, Christophe Dessimoz   +2 more
doaj   +1 more source