Results 41 to 50 of about 308,702 (255)
PLoS ONE, 2013 UnlabelledThe primary means of classifying new functions for genes and proteins relies on Gene Ontology (GO), which defines genes/proteins using a controlled vocabulary in terms of their Molecular Function, Biological Process and Cellular Component.
Mario Fruzangohar +5 more
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CirGO: an alternative circular way of visualising gene ontology terms
BMC Bioinformatics, 2019 Background Prioritisation of gene ontology terms from differential gene expression analyses in a two-dimensional format remains a challenge with exponentially growing data volumes.
Irina Kuznetsova +4 more
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BMC Genomics, 2010 Background There is increasing evidence that gene location and surrounding genes influence the functionality of genes in the eukaryotic genome. Knowing the Gene Ontology Slim terms associated with a gene gives us insight into a gene's functionality by ...
Tsatsoulis Costas, Amthauer Heather A
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InfAcrOnt: calculating cross-ontology term similarities using information flow by a random walk
BMC Genomics, 2018 Background Since the establishment of the first biomedical ontology Gene Ontology (GO), the number of biomedical ontology has increased dramatically. Nowadays over 300 ontologies have been built including extensively used Disease Ontology (DO) and Human ...
Liang Cheng +6 more
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The Gene Ontology Annotation (GOA) Database: sharing knowledge in Uniprot with Gene Ontology [PDF]
Nucleic Acids Research, 2004 The Gene Ontology Annotation (GOA) database (http://www.ebi.ac.uk/GOA) aims to provide high-quality electronic and manual annotations to the UniProt Knowledgebase (Swiss-Prot, TrEMBL and PIR-PSD) using the standardized vocabulary of the Gene Ontology (GO).
Evelyn Camon +9 more
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Multi-label literature classification based on the Gene Ontology graph
BMC Bioinformatics, 2008 Background The Gene Ontology is a controlled vocabulary for representing knowledge related to genes and proteins in a computable form. The current effort of manually annotating proteins with the Gene Ontology is outpaced by the rate of accumulation of ...
Lu Xinghua +3 more
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Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Defining functional distances over Gene Ontology
BMC Bioinformatics, 2008 Background A fundamental problem when trying to define the functional relationships between proteins is the difficulty in quantifying functional similarities, even when well-structured ontologies exist regarding the activity of proteins (i.e.
del Pozo Angela +2 more
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On gene ontology and function annotation [PDF]
Bioinformation, 2006 The effort of function annotation does not merely involve associating a gene with some structured vocabulary that describes action. Rather the details of the actions, the components of the actions, the larger context of the actions are important issues that are of direct relevance, because they help understand the biological system to which the gene ...
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Extending gene ontology with gene association networks [PDF]
Bioinformatics, 2015 Abstract Motivation: Gene ontology (GO) is a widely used resource to describe the attributes for gene products. However, automatic GO maintenance remains to be difficult because of the complex logical reasoning and the need of biological knowledge that are not explicitly represented in the GO.
Jiajie Peng +4 more
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