Results 31 to 40 of about 3,013,569 (257)

The association of cytokine gene polymorphisms with the development and course of COVID-19

Журнал инфектологии
Objective: to study polymorphic variants of IL-2 (T330G), IL-10 (A592C), IL-6 (rs180795), INF a/b receptor (rs9984273), INFL4 (rs368234815), INFL3 (rs12979860), INF-γ (rs2430561) genes in COVID-19 patients to determine the risk of development and ...
N. I. Baranova, L. A. Ashchina, O. A. Kulieva, A. I. Bolgova   +3 more
doaj   +1 more source

Impulsive traits and 5-HT2A receptor promoter polymorphism in alcohol dependents: Possible association but no influence of personality disorders [PDF]

, 2001
Objective: Impulsive behavior in alcoholics puts them at serious risk of severer course of disease and has been related to the serotonergic neurotransmission dysfunction.
Bondy, Brigitta, Preuss, Ulrich W., Soyka, Michael, Bahlmann, Miriam, Koller, G.   +4 more
core   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

4G/5G polymorphism of PAI-1 gene is associated with multiple organ dysfunction and septic shock in pneumonia induced severe sepsis: prospective, observational, genetic study. [PDF]

, 2010
In Caucasian patients with severe sepsis due to pneumonia carriers of the 4G allele of PAI-1 polymorphism have higher risk for multiple organ dysfunction syndrome and septic shock and in agreement they showed more fulminant disease progression based on ...
Aladzsity, István, Prohászka Zoltán, Madách Krisztina, Füst György, Pénzes, István, Gál János, Pénzes István, Madách, Krisztina, Prohászka, Zoltán, Szilágyi Ágnes, Aladzsity István, Szilágyi, Agnes, Fust, George, Gál, János   +13 more
core   +1 more source

IMPACT OF POLYMORPHISM OF CARDIOVASCULAR RISK GENES ON ARTERIAL REMODELLING DEVELOPMENT DEPENDING ON PRESENCE OF SYSTEMIC HYPERTENSION

Российский кардиологический журнал, 2018
Aim. To investigate on clinical and genetic characteristics of patients with multiple cardiovascular risk factors depending on the presence or absence of arterial hypertension (AH) and severity of pure arterial stiffness.Material and methods.
A. I. Chernyavina, M. V. Surovtseva
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

The rs1990760 polymorphism within the IFIH 1 locus is not associated with Graves' disease, Hashimoto's thyroiditis and Addison's disease [PDF]

, 2009
Background: Three genes have been confirmed as major joint susceptibility genes for endocrine autoimmune disease:human leukocyte antigen class II, cytotoxic T-lymphocyte antigen 4 and protein tyrosine phosphatase non-receptor type 22.
Reisch, Nicole, Badenhoop Klaus, Elizabeth Ramos Lopez, Stefanie Hahner, H. Willemberg, Segni, Maria, Kahles Heinrich, Inka Robbers, Ramos-Lopez, Elizabeth, Hahner, Stefanie, Heinrich Kahles, Willenberg, Holger, Robbers Inka, Seidl, Christian, Marissa Penna Martinez, Christian Seidl, Willenberg, Holger S., Reisch Nicole, Kahles, Heinrich, Penna-Martinez Marissa, Klaus Badenhoop, Penna Martinez, Marissa, Seidl Christian, Badenhoop, Klaus, Robbers, Inka, Penna-Martinez, Marissa, Ramos-Lopez Elizabeth, Hahner Stefanie, Segni Maria, Willenberg Holger, Nicole Reisch   +30 more
core   +1 more source

Investigating the Distribution of ERCC2 (rs13181) Gene Polymorphism in Gastric Cancer Patients in Mazandaran: A Case-control Study [PDF]

Journal of Genetic Resources, 2017
Background and objectives: Gastric cancer is one of the most common cancers of the gastrointestinal tract in the world, which also has a high prevalence in Iran. ERCC2 gene is considered one of the major genes related to gastric cancer. The present study
Mohammad Shokrzadeh, Abbas Mohammadpour, Yahya Saleh Tabari, Sara Parvizi Almani   +3 more
doaj   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Impact of mating systems on patterns of sequence polymorphism in flowering plants [PDF]

, 2006
A fundamental challenge in population genetics and molecular evolution is to understand the forces shaping the patterns of genetic diversity within and among species.
Deborah Charlesworth, Bazin, Eric, Eric Bazin, Glemin, Sylvain, Sylvain Glémin, Charlesworth, Deborah   +5 more
core   +1 more source