Results 41 to 50 of about 3,013,569 (257)

Relationship Between BIM Gene Polymorphism and Therapeutic Efficacy in the 
Retreatment of Advanced Non-small Cell Lung Cancer with Tyrosine Kinase Inhibitor

Chinese Journal of Lung Cancer, 2013
Background and objective BIM gene is a member of the BCL-2 family, is involved in cell death. The aim of this study is to explore the relationship between BIM gene polymorphism and therapeutic efficacy in the retreatment advanced non-small cell lung ...
Lei ZHENG, Baochai LIN, Zhengbo SONG, Fangjun XIE, Wei HONG, Jianguo FENG, Lan SHAO, Yingping ZHANG   +7 more
doaj   +1 more source

PPAR-γ and CYP46A1 genes polymorphism is associated with Primary Open Angle Glaucoma (POAG) in hypertensive North Indians

Egyptian Journal of Medical Human Genetics, 2017
Background: Involvement of genetic factors like gene polymorphisms was found to contribute significantly to development and progression of Primary Open Angle Glaucoma (POAG) in the last few decades.
Syed Tasleem Raza, Saliha Rizvi, Luxmi Singh, Shania Abbas, Zeashan Haider Zaidi, Farzana Mahdi   +5 more
doaj   +1 more source

Lysyl oxidase (LOX)‐mediated remodeling of the extracellular matrix

FEBS Letters, EarlyView.
The lysyl oxidase (LOX) family of enzymes drives extracellular matrix remodeling by oxidizing collagen, elastin, and fibronectin, promoting covalent cross‐link formation. This activity regulates tissue architecture and mechanical properties, while its dysregulation contributes to fibrosis, cardiovascular disease, glaucoma, connective tissue disorders ...
Fernando Rodríguez‐Pascual, Marta Navarro‐Gutiérrez, Verónica Romero‐Albillo, Raquel Jiménez‐Sánchez   +3 more
wiley   +1 more source

Influence of the MDM2 single nucleotide polymorphism SNP309 on tumour development in BRCA1 mutation carriers [PDF]

, 2006
BackgroundThe MDM2 gene encodes a negative regulator of the p53 tumour suppressor protein. A single nucleotide polymorphism (SNP) in the MDM2 promoter (a T to G exchange at nucleotide 309) has been reported to produce accelerated tumour formation in ...
Johnson, Peter W., White Helen E, Jeremy P Blaydes, Diana M Eccles, White, Helen E., Ellen R Copson, Johnson Peter W, Eccles Diana M, Eccles, Diana M., Helen E White, Robinson, David O., David O Robinson, Peter W Johnson, Blaydes, Jeremy P., Copson, Ellen R., Robinson David O, Copson Ellen R, Blaydes Jeremy P   +17 more
core   +2 more sources

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

The association between 331A/T polymorphism in the SHH gene and 385G/A polymorphism in the SMO gene and the development of basal cell carcinomas

, 2014
Introduction. Basal cell carcinomas (BCCs) are the most common of all cancers in the Caucasians, and their incidence has been rising in younger populations.
Karolina Wódz, Dorota Sobolewska-Sztychny, Michał Sobjanek, Joanna Narbutt, Joanna Sieniawska, Anna Woźniacka, Aleksandra Lesiak   +6 more
core   +1 more source

The SOD2 C47T polymorphism influences NAFLD fibrosis severity: evidence from case-control and intra-familial allele association studies. [PDF]

, 2011
AIMS: Non-alcoholic fatty liver disease (NAFLD) is a complex disease trait where genetic variations and environment interact to determine disease progression.
Patch, Julia, J. Patch, Ann K. Daly, J. B. S. Leathart, Quentin M. Anstee, Julian B.S. Leathart, Julia Patch, Christopher P. Day, Nobili, Valerio, Valerio Nobili, Anna Fracanzani, Silvia Fargion, Q. M. Anstee, Leathart, Julian B S, Day, Christopher P, Daly, Ann K, L. Valenti, Ahmad Al-Serri, S. Fargion, Paola Dongiovanni, Al Serri, Ahmad, Anstee, Quentin M, Fracanzani, Anna, Dongiovanni, Paola, C. P. Day, A. Fracanzani, A. Al Serri, V. Nobili, A. K. Daly, Valenti, Luca, P. Dongiovanni, Luca Valenti, Fargion, Silvia   +32 more
core   +1 more source

Associations between the K232A polymorphism in the diacylglycerol-O-transferase 1 (DGAT1) gene and performance in Irish Holstein-Friesian dairy cattle [PDF]

, 2010
peer-reviewedSelection based on genetic polymorphisms requires accurate quantification of the effect or association of the polymorphisms with all traits of economic importance. The objective of this study was to estimate, using progeny performance data
McCabe, Matthew, Waters, Sinead M., Kearney, J.F., Howard, Dawn J., O'Boyle, Padraig, Berry, Donagh   +5 more
core   +1 more source

Pharmacogenetic aspects of eprosartan therapy and polymorphic markers of renin-angiotensin-aldosterone system genes in Uzbek patients with essential arterial hypertension

Кардиоваскулярная терапия и профилактика, 2009
Aim. To investigate antihypertensive and anti-remodeling effects of eprosartan in Uzbek patients with essential arterial hypertension (AH), taking into consideration renin-angiotensin-aldosterone system genetic polymorphism.Material and methods.
D. R. Kurbanova, N. Z. Srozhidinova, N. B. Tursunova, M. R. Eliseeva   +3 more
doaj  

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source