Results 21 to 30 of about 357,869 (263)

GENE POLYMORPHISM;

The Professional Medical Journal, 2019
Introduction: Reduced bone density in postmenopausal women is a complex disease with a strong genetic association. Causative factors are both acquired and genetic. Single nucleotide polymorphisms may be associated with genetic predisposition of this condition. Objectives: The purpose of this study is to find out an association between single nucleotide
Amal Shoukat, Farwa Naqvi, Imran Aftab, Amna Mubeen, Bilal Habib, Shoaib Ahmed   +5 more
openaire   +2 more sources

The association of cytokine gene polymorphisms with the development and course of COVID-19

Журнал инфектологии
Objective: to study polymorphic variants of IL-2 (T330G), IL-10 (A592C), IL-6 (rs180795), INF a/b receptor (rs9984273), INFL4 (rs368234815), INFL3 (rs12979860), INF-γ (rs2430561) genes in COVID-19 patients to determine the risk of development and ...
N. I. Baranova, L. A. Ashchina, O. A. Kulieva, A. I. Bolgova   +3 more
doaj   +1 more source

Analysis of rs7895833 polymorphism of SIRT1 gene and its influence on the risk occurrence and progression of neurodegenerative disease, such as primary open-angle glaucoma in a Polish population

Journal of Pre-Clinical and Clinical Research, 2022
Introduction and objective A neurodegenerative disease, which is primary open-angle glaucoma (POAG) through damage of the optic nerve, leads to irreversible loss of vision.
Mateusz Siwak, Marcin Maślankiewicz, Alicja Nowak-Zduńczyk, Beata Filipek, Radosław Wojtczak, Maciej Radek, Ewa Kucharska, Jerzy Szaflik, Jacek Paweł Szaflik, Ireneusz Jacek Majsterek   +9 more
doaj   +1 more source

The extensive polymorphism of KIR genes [PDF]

Immunology, 2009
SummaryThe functions of human natural killer (NK) cells are controlled by diverse families of antigen receptors. Prominent among these are the killer cell immunoglobulin‐like receptors (KIR), a family of genes clustered in one of the most variable regions of the human genome.
Derek, Middleton, Faviel, Gonzelez
openaire   +2 more sources

IMPACT OF POLYMORPHISM OF CARDIOVASCULAR RISK GENES ON ARTERIAL REMODELLING DEVELOPMENT DEPENDING ON PRESENCE OF SYSTEMIC HYPERTENSION

Российский кардиологический журнал, 2018
Aim. To investigate on clinical and genetic characteristics of patients with multiple cardiovascular risk factors depending on the presence or absence of arterial hypertension (AH) and severity of pure arterial stiffness.Material and methods.
A. I. Chernyavina, M. V. Surovtseva
doaj   +1 more source

Investigating the Distribution of ERCC2 (rs13181) Gene Polymorphism in Gastric Cancer Patients in Mazandaran: A Case-control Study [PDF]

Journal of Genetic Resources, 2017
Background and objectives: Gastric cancer is one of the most common cancers of the gastrointestinal tract in the world, which also has a high prevalence in Iran. ERCC2 gene is considered one of the major genes related to gastric cancer. The present study
Mohammad Shokrzadeh, Abbas Mohammadpour, Yahya Saleh Tabari, Sara Parvizi Almani   +3 more
doaj   +1 more source

Natural Killer Cells in Paediatric Soft Tissue Sarcomas: A Systematic Review

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Paediatric soft tissue sarcomas (pSTS) are a rare and heterogeneous group of malignant tumours arising in tissues of mesenchymal origin. The role of natural killer (NK) cells in pSTS remains poorly understood, with evidence fragmented across small preclinical studies and early‐phase clinical trials.
Raya Dean, Lara V. Graham, Christina Putnam, Rosa Gomes Alves Martins, Daniel T. Harding, Tim J. Underwood, Zoë S. Walters, Matthew D. Blunt   +7 more
wiley   +1 more source

DVWA gene polymorphisms and osteoarthritis

BMC Research Notes, 2015
Osteoarthritis (OA) is a degenerative joints disorder influenced by genetic predisposition. We reported that rs11718863 DVWA SNP was represented in Sicilian with a more severe Kellgren and Lawrence (KL) radiographic grade, displaying its predictive role as OA marker progression.
Valentina Bravatà 1*, Luigi Minafra 1*, Giusi I Forte 1, Francesco P Cammarata 1, Michele Saporito 2, Filippo Boniforti 3, Domenico Lio 4, Maria C Gilardi 1, 5, 6, Cristina Messa 1, 6, 7   +12 more
openaire   +5 more sources

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

PPAR-γ and CYP46A1 genes polymorphism is associated with Primary Open Angle Glaucoma (POAG) in hypertensive North Indians

Egyptian Journal of Medical Human Genetics, 2017
Background: Involvement of genetic factors like gene polymorphisms was found to contribute significantly to development and progression of Primary Open Angle Glaucoma (POAG) in the last few decades.
Syed Tasleem Raza, Saliha Rizvi, Luxmi Singh, Shania Abbas, Zeashan Haider Zaidi, Farzana Mahdi   +5 more
doaj   +1 more source