Results 1 to 10 of about 7,390,551 (401)

The Association Between CTLA-4, CD80/86, and CD28 Gene Polymorphisms and Rheumatoid Arthritis: An Original Study and Meta-Analysis

Frontiers in Medicine, 2021
Background: Rheumatoid arthritis (RA) is related to several pivotal susceptibility genes, including cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) and costimulatory molecule (CD80/CD86) genes. Although the connection between polymorphisms of CTLA-4
Weixi Liu, Zhicheng Yang, Yan Chen, Haoyu Yang, Xiaoxian Wan, Xindie Zhou, Ruiping Liu, Yunkun Zhang   +7 more
doaj   +1 more source

Toll-Like Receptors Gene Polymorphisms in Autoimmune Disease

Frontiers in Immunology, 2021
Toll-like receptors (TLRs) are important initiators of the immune response, both innate and acquired. Evidence suggests that gene polymorphisms within TLRs cause malfunctions of certain key TLR-related signaling pathways, which subsequently increases the
Yingchi Zhang, Jia Liu, Changlun Wang, Junxian Liu, W. Lu   +4 more
semanticscholar   +1 more source

Investigation of biomarkers in Endometriosis-associated infertility: Systematic Review

Anais da Academia Brasileira de Ciências, 2022
The relationship between endometriosis and infertility is still unknown, but it is possible that genetic polymorphisms influence these two variables. This study aims to identify, in the literature, which polymorphisms are related to infertility in women ...
ERIKA M. EGASHIRA, ALESSANDRA B. TROVÓ-MARQUI, SARAH C.S.V. TANAKA, MARIANGELA T.R. CINTRA   +3 more
doaj   +1 more source

Vitamin D receptor gene polymorphisms and prognosis of breast cancer among African-American and Hispanic women. [PDF]

, 2013
BackgroundVitamin D plays a role in cancer development and acts through the vitamin D receptor (VDR). Although African-Americans have the lowest levels of serum vitamin D, there is a dearth of information on VDR gene polymorphisms and breast cancer among
Chen, Zujian, Heber, David, Koeffler, H Phillip, Mishra, Dhruva K, Ong, May, Sarkissyan, Marianna, Sarkissyan, Suren, Shang, Xiying, Vadgama, Jaydutt V, Wu, Yanyuan   +9 more
core   +16 more sources

Innate Immune Responses in Pediatric Patients with Gastritis—A Trademark of Infection or Chronic Inflammation?

Children, 2022
The aim of this study was to define the relationship between several environmental, laboratory, and genetic factors, i.e., TLR2 and NLRP3 polymorphisms, and Helicobacter pylori (H.
Lorena Elena Meliț, Cristina Oana Mărginean, Maria Oana Săsăran, Simona Mocanu, Dana Valentina Ghiga, Adriana Crișan, Claudia Bănescu   +6 more
doaj   +1 more source

Gene polymorphisms of inflammatory factors in liver cirrhosis

Frontiers in Genetics, 2023
Introduction: Studies on the association between gene polymorphisms of various inflammatory factors and liver cirrhosis have been inconsistent. The purpose of this study was to comprehensively summarize the available evidence on the association between ...
Sailan Xiao, Xiongfeng Pan, Xun Huang, Yamin Liu, Shi Wu Wen, Shi Wu Wen, Shi Wu Wen, Aizhong Liu, Aizhong Liu   +8 more
doaj   +1 more source

Polymorphisms of candidate genes determining the clinical and hemostasiological characteristics of endocarditis of various etiology

Бюллетень сибирской медицины, 2022
Aim. To investigate polymorphisms of 18 genes as possible molecular genetic markers of predisposition or resistance to development of non-infective (NE) or infective endocarditis (IE).Materials and methods.
Y. S. Bakhareva, V. N. Maksimov, A. A. Ivanova, N. N. Chapaeva, S. V. Aidagulova, M. I. Voevoda   +5 more
doaj   +1 more source

Vitamin D receptor gene polymorphisms and idiopathic Parkinson disease: an Egyptian study

The Egyptian Journal of Neurology, Psychiatry and Neurosurgery, 2021
Background Accumulating data have suggested that vitamin D receptor (VDR) gene is a pretender gene for vulnerability to Parkinson disease (PD). This study aimed to assess the relationship of VDR gene polymorphisms (FokI and ApaI) with PD.
Ebtesam Mohamed Fahmy, Mohamed Elsayed Elawady, Sahar Sharaf, Sarah Heneidy, Rania Shehata Ismail   +4 more
doaj   +1 more source

The Association between Circadian Clock Gene Polymorphisms and Metabolic Syndrome: A Systematic Review and Meta-Analysis

Biology, 2021
Metabolic syndrome (MetS) is a combination of cardiovascular risk factors associated with type 2 diabetes, obesity, and cardiovascular diseases. The circadian clock gene polymorphisms are very likely to participate in metabolic syndrome genesis and ...
Ivana Škrlec, Jasminka Talapko, Snježana Džijan, Vera Cesar, Nikolina Lazić, Hrvoje Lepeduš   +5 more
doaj   +1 more source

Association between HLA gene polymorphisms and mortality of COVID‐19: An in silico analysis

Immunity, Inflammation and Disease, 2020
The emergence of SARS‐CoV‐2 has caused global public health and economic crisis. Human leukocyte antigen (HLA) is a critical component of the viral antigen presentation pathway and plays essential roles in conferring differential viral susceptibility and
Y. Tomita, T. Ikeda, R. Sato, T. Sakagami   +3 more
semanticscholar   +1 more source