Results 41 to 50 of about 396,263 (266)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

ORTHOPTERA (ORTHOPTERA: ACRIDIDAE) OF UZBEKISTAN ARE INTERMEDIATE HOSTS OF FILARIIDS OF BIRDS

Российский паразитологический журнал, 2019
Objective of research: The study of biology and life cycles of some filarial species - parasites of birds in Uzbekistan. Material and methods. More than 15 thousand orthopterans of the family Acrididae were collected and studied according to the standard
F. D. Akramova, M. J. Medetov, U. A. Shakarbaev, D. A. Azimov, K. A. Saparov   +4 more
doaj  

RNA sequencing and genome-wide association analysis reveal key genes responsible for different feather colors in Youjiang goose

Poultry Science
Goose feathers have various colors, including black, white, brown, and gray, in addition to stripes and spots of different colors. The Youjiang goose is bred under specific ecological and climatic conditions in Jiangxi Province, China.
Mengli Zhao, Xiaoming Li, Jian Wang, Lei Zhang, Haiyue Cao, Meng Wu, Hongchang Zhao, Rongchao Ji, Gansheng Zhang, Guoshun Chen, Xiujun Duan   +10 more
doaj   +1 more source

Testing Domestication Scenarios of Lima Bean (Phaseolus lunatus L.) in Mesoamerica: Insights from Genome-Wide Genetic Markers

Frontiers in Plant Science, 2017
Plant domestication can be seen as a long-term process that involves a complex interplay among demographic processes and evolutionary forces. Previous studies have suggested two domestication scenarios for Lima bean in Mesoamerica: two separate ...
María I. Chacón-Sánchez, Jaime Martínez-Castillo   +1 more
doaj   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Inbreeding and the Gene Pool

Journal of Dairy Science, 1984
The trend in the artificial insemination industry in recent years has been to sample larger numbers of sons sired by the most popular bulls. This trend has caused concern in the dairy industry regarding inbreeding and the gene pool. The known detrimental effects of inbreeding on economically important traits are one reason for this concern, and these ...
openaire   +2 more sources

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Antibiogram and molecular insights into quinolone resistance in Salmonella spp. from food-producing animals in the Philippines

Journal of Infection in Developing Countries
Introduction: The increasing quinolone resistance in food animals in the Philippines has been documented in previous studies. This study aims to investigate the prevalence and underlying molecular mechanisms responsible for quinolone non-susceptibility ...
Lawrence P Belotindos, Angel Mae C Magalong, Marvin Bryan S Salinas, Joel A Miguel Jr., Marvin A Villanueva, Claro N Mingala, Chie Nakajima, Yasuhiko Suzuki   +7 more
doaj   +1 more source

Phytogeographical origin of Madeiran common beans based on phaseolin patterns Origem fitogeográfica de feijões da Madeira com base em perfis de faseolina

Pesquisa Agropecuária Brasileira, 2010
The objective of this work was to determine the geographic origin of the Madeiran common bean (Phaseolus vulgaris) gene pool. Phaseolin patterns of 50 accessions representing the diversity of common bean collected in Madeira, Portugal, and conserved in ...
Emanuel Marques da Silva, Anísia Soraia Abreu Correia, Nuno Alexandre Amaral Lopes, Humberto Gil Moreira Nóbrega, José Filipe Teixeira Ganança, Ana Maria Domingues, Manhaz Khadem, Jan Jacek Slaski, Miguel Ângelo Almeida Pinheiro de Carvalho   +8 more
doaj   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source