Results 51 to 60 of about 3,252,139 (303)
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Fauna and ecology of Spirurida in cattle of Uzbekistan
Российский паразитологический журнал, 2019 Objective of research: The objective of this study was to investigate the fauna, features of distribution and ecology of nematodes of the order Spirurida - parasites of cattle from Uzbekistan. Material and methods.
F. D. Akramova +5 more
doaj
Open Veterinary JournalBackground: Food safety is essential for public health. Food products from animals and farm environments can serve as vehicles for the transmission of antibiotic-resistant bacteria and resistance genes to humans.
Shaira S. De Gracia +7 more
doaj +1 more source
Вавиловский журнал генетики и селекции, 2019 Paleogenomic studies of recent years have shown that the Bronze Age migrations of populations of the PontoCaspian steppes from the east to the west of Europe had a great influence on the formation of the genetic makeup of modern Europeans. The results of
B. A. Malyarchuk
doaj +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
ORTHOPTERA (ORTHOPTERA: ACRIDIDAE) OF UZBEKISTAN ARE INTERMEDIATE HOSTS OF FILARIIDS OF BIRDS
Российский паразитологический журнал, 2019 Objective of research: The study of biology and life cycles of some filarial species - parasites of birds in Uzbekistan. Material and methods. More than 15 thousand orthopterans of the family Acrididae were collected and studied according to the standard
F. D. Akramova +4 more
doaj
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Understanding climate change impacts on water buffalo production through farmers’ perceptions
Climate Risk Management, 2018 Climate variability and change will increasingly harm crop and livestock systems worldwide. Evidence of climate change impacts are largely documented for crops with much less information for livestock.
Jacquelyn F. Escarcha +3 more
doaj +1 more source
Fishing for Function in the Human Gene Pool
Trends in Genetics, 2016 Identification and characterization of causal non-coding variants in human genomes is challenging and requires substantial experimental resources. A new study by Tehranchi et al. describes a cost-effective approach for accurate mapping of molecular quantitative trait loci (QTLs) from pooled samples, a powerful way to link disease-associated changes to ...
Barozzi, Iros +2 more
openaire +4 more sources
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source