Results 71 to 80 of about 3,252,139 (303)

Impact of low-protein diet on geese growth: early low-protein diets with amino acid supplementation improve nitrogen utilization and maintain growth performance in meat geese

Frontiers in Animal Science
Herein, 364 one-day-old male Jiangnan white goslings were divided into four groups: PM (18.55% crude protein (CP) + main amino acids (AA)), PA (18.55% CP + all AA), LPM (15.55% CP + main AA), and LPA (15.55% CP + all AA). The main AAs were Lys, Met, Thr,
Wenzhong Li, Mengli Zhao, Mengli Zhao, Lei Zhang, Guobo Sun, Hongchang Zhao, Gansheng Zhang, Rongchao Ji, Jian Wang, Jian Wang, Xiaoming Li, Xiaoming Li, Xiaoming Li, Guoshun Chen   +13 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Association of the CCR5 gene with juvenile idiopathic arthritis [PDF]

, 2010
The CC chemokine receptor 5 (CCR5) has been shown to be important in the recruitment of T-helper cells to the synovium, where they accumulate, drive the inflammatory process and the consequent synovitis and joint destruction.
Martin, P., BSPAR Study Group, Barton, A., UKRAG Consortium, Worthington, J., Gardner-Medwin, J. [CAPS and BSPAR Study Groups], Thomson, W., W Thomson, Flynn, E., A Hinks, E Flynn, J Packham, Packham, J., Hinks, A., S Eyre, J Worthington, Eyre, S.; id_orcid, Eyre, S., Barton, A.; id_orcid, P Martin, Childhood Arthritis Prospective Study (CAPS), Martin, P.; id_orcid, A Barton   +22 more
core   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Decrypting the Mitochondrial Gene Pool of Modern Panamanians

PLoS ONE, 2012
El istmo de Panamá, la estrecha franja de tierra que conecta las masas terrestres del norte y sur de América, era un corredor obligatorio para los paleoindios cuando se mudaron a América del Sur. La evidencia arqueológica sugiere un vínculo ininterrumpido entre los nativos modernos y sus antepasados paleoindios en algunas áreas de Panamá, incluso si ...
Ugo A. Perego, Hovirag Lancioni, Maribel Tribaldos, Norman Angerhofer, Jayne E. Ekins, Anna Olivieri, Scott R. Woodward, Juan Miguel Pascale, Richard G. Cooke, Jorge Motta, Alessandro Achilli   +10 more
openaire   +6 more sources

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

ON PHYSIOLOGICAL MECHANISM OF SALIVARY SECRETION IN TICKS ARGAS PERSICUS OKEN, 1818 (ARGASIDAE, ARGAS)

Российский паразитологический журнал, 2016
The anticoagulant effect of salivary secretion of ticks Argas persicus was studied. The experiments were conducted on aorta preparations isolated from the chest of white outbread rats.
A. U. Mirzayeva, F. D. Akramova, S. Sh. Hushmatov   +2 more
doaj  

Oregon Medical Insurance Pool frequently asked questions

, 2007
This archived document is maintained by the Oregon State Library as part of the Oregon Documents Depository Program. It is for informational purposes and may not be suitable for legal purposes.Title from Web page (viewed on Apr. 25, 2007)"Last modified:

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