Results 91 to 100 of about 859,450 (301)

Whole-proteome tree of life suggests a deep burst of organism diversity. [PDF]

, 2020
An organism tree of life (organism ToL) is a conceptual and metaphorical tree to capture a simplified narrative of the evolutionary course and kinship among the extant organisms.
Choi, JaeJin, Kim, Sung-Hou
core  

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Gene Editing Technology and the Human Gene Pool

Zygon
This article explores the implications of gene editing technologies, particularly focusing on medical applications and future possibilities. It also discusses approaches to gene editing, beginning with plant manipulation up until modern day, when CRISPR ...
Gayle E. Woloschak
doaj   +2 more sources

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

The passport database of VIR’s bean collection as a tool for systemizing bean genetic diversity, studying the collection’s history, and monitoring the crop’s worldwide breeding (an overview)

Труды по прикладной ботанике, генетике и селекции, 2019
The main document attesting the composition of a collection is the passport database (DB), which contains basic information about every accession: its name, status, origin, the year of its placement into the collection, etc.
T. V. Buravtseva, G. P. Egorova, M. A. Vishnyakova   +2 more
doaj   +1 more source

Parameterless Gene-Pool Optimal Mixing Evolutionary Algorithms

Evolutionary Computation
Abstract When it comes to solving optimization problems with evolutionary algorithms (EAs) in a reliable and scalable manner, detecting and exploiting linkage information, that is, dependencies between variables, can be key. In this paper, we present the latest version of, and propose substantial enhancements to, the gene-pool optimal ...
Arkadiy Dushatskiy, Marco Virgolin, Anton Bouter, Dirk Thierens, Peter A. N. Bosman   +4 more
openaire   +4 more sources

Sex-biased mouse liver lincRNAs: validation and impact of mouse knockout models that perturb hepatic growth signaling [PDF]

, 2016
Sexual dimorphism has a broad impact on human health and disease, including autoimmune diseases, cardiovascular diseases, and liver diseases, specifically hepatocellular carcinoma.
Yilmaz, Feyza
core   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

CREATION AND USE OF THE GENE POOL OF ONION PLANTS IN SIBERIA

Овощи России, 2018
The main results of research on onion crops in the laboratory of seed selection and technology of cultivation of vegetable cultures of SibNIIRS for a 40-year period are given.
T. V. Steinert, A. V. Aliluev, L. M. Avdeenko, Е. G. Grinberg   +3 more
doaj   +1 more source