Results 101 to 110 of about 563,010 (309)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

STPath: a generative foundation model for integrating spatial transcriptomics and whole-slide images

npj Digital Medicine
Spatial transcriptomics (ST) offers insights into gene expression patterns and their spatial context within the tumor microenvironment, but remains limited by the scalability of current sequencing technologies.
Tinglin Huang, Tianyu Liu, Mehrtash Babadi, Rex Ying, Wengong Jin   +4 more
doaj   +1 more source

Integrating Gene Expression Data into Single-Step Method (ssBLUP) Improves Genomic Prediction Accuracy for Complex Traits of Duroc × Erhualian F₂ Pig Population

Current Issues in Molecular Biology
The development of multi-omics has increased the likelihood of further improving genomic prediction (GP) of complex traits. Gene expression data can directly reflect the genotype effect, and thus, they are widely used for GP.
Fangjun Xu, Zhaoxuan Che, Jiakun Qiao, Pingping Han, Na Miao, Xiangyu Dai, Yuhua Fu, Xinyun Li, Mengjin Zhu   +8 more
doaj   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Prediction of cis-regulatory elements controlling genes differentially expressed by retinal and choroidal vascular endothelial cells [PDF]

, 2008
Dongseok Choi, Binoy Appukuttan, Sierra J. Binek, Stephen R. Planck, J. Timothy Stout, James T. Rosenbaum, Justine R. Smith   +6 more
openalex   +1 more source

R400: A novel gene signature for dose prediction in radiation exposure studies in humans

, 2022
Frederick St. Peter, Srinivas Mukund Vadrev, Othman Soufan   +2 more
openalex   +1 more source

Single Nucleotide Polymorphism (SNP) in splice sites and prediction for the doublesex (dsx) gene alternative splicing in the malaria vector Anopheles gambiae. [PDF]

, 2020
Oswald Djihinto, Helga Saizonou, Luc Djogbénou   +2 more
openalex   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Identification of a Novel Ferroptosis-Related Gene Prediction Model for Clinical Prognosis and Immunotherapy of Colorectal Cancer [PDF]

, 2021
Yabing Yang, Jiaxin Zhou, Shenghui Qiu, Jiashuai He, Jinghua Pan, Yun-long Pan   +5 more
openalex   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source