Results 111 to 120 of about 9,911,867 (381)
Galba: genome annotation with miniprot and AUGUSTUS
BMC Bioinformatics, 2023 Background The Earth Biogenome Project has rapidly increased the number of available eukaryotic genomes, but most released genomes continue to lack annotation of protein-coding genes.
Tomáš Brůna +9 more
doaj +1 more source
Engineering genes for predictable protein expression
Protein Expression and Purification, 2012 The DNA sequence used to encode a polypeptide can have dramatic effects on its expression. Lack of readily available tools has until recently inhibited meaningful experimental investigation of this phenomenon. Advances in synthetic biology and the application of modern engineering approaches now provide the tools for systematic analysis of the sequence
Sridhar Govindarajan +5 more
openaire +3 more sources
Cancer cell death induced by the NAD antimetabolite Vacor discloses the antitumor potential of SARM1
FEBS Letters, EarlyView.Vacor, a compound converted into the toxic metabolite Vacor adenine dinucleotide (VAD) by the nicotinamide salvage pathway enzymes NAMPT and NMNAT2, exhibits antitumor activity by inducing rapid and complete NAD depletion. We report that Vacor toxicity is limited to cell lines expressing high levels of SARM1, a NAD glycohydrolase.
Giuseppe Ranieri +5 more
wiley +1 more source
Biological process annotation of proteins across the plant kingdom
Current Plant Biology, 2014 Accurate annotation of protein function is key to understanding life at the molecular level, but automated annotation of functions is challenging.
Joachim W. Bargsten +4 more
doaj +1 more source
Predictability of human differential gene expression [PDF]
Proceedings of the National Academy of Sciences, 2019 Differential expression (DE) is commonly used to explore molecular mechanisms of biological conditions. While many studies report significant results between their groups of interest, the degree to which results are specific to the question at hand is not generally assessed, potentially leading to inaccurate interpretation.
Crow, M +4 more
openaire +3 more sources
RAD50 missense variants differentially affect the DNA damage response and mitotic progression
FEBS Letters, EarlyView.RAD50 incorporates into the MRN complex and initiates the DNA damage response. Furthermore, RAD50 promotes mitotic progression. RAD50 missense variants capable of forming an MRN complex supported the DNA damage response and mitotic features to different extents in complementation experiments, indicating these functions are separable and might impact ...
Hanna Redeker +9 more
wiley +1 more source
A Digital Signal Processing Method for Gene Prediction with Improved Noise Suppression
EURASIP Journal on Advances in Signal Processing, 2004 It has been observed that the protein-coding regions of DNA sequences exhibit period-three behaviour, which can be exploited to predict the location of coding regions within genes.
Carreira Alex, Fox Trevor W
doaj +1 more source
The effect of sequencing errors on metagenomic gene prediction
BMC Genomics, 2009 Background Gene prediction is an essential step in the annotation of metagenomic sequencing reads. Since most metagenomic reads cannot be assembled into long contigs, specialized statistical gene prediction tools have been developed for short and ...
Hoff Katharina J
doaj +1 more source
BMC Bioinformatics, 2016 Gene prediction is one of the most important steps in the genome annotation process. A large number of software tools and pipelines developed by various computing techniques are available for gene prediction. However, these systems have yet to accurately
K. Chan +5 more
semanticscholar +1 more source
Gene prediction by multiple syntenic alignment [PDF]
Journal of Integrative Bioinformatics, 2005 Summary Given the increasing number of available genomic sequences, one now faces the task of identifying their functional parts, like the protein coding regions. The gene prediction problem can be addressed in several ways. One of the most promising methods makes use of similarity information between the genomic DNA and previously annotated sequences (
Said Sadique Adi +1 more
openaire +3 more sources