Results 121 to 130 of about 9,911,867 (381)

HOX Gene Promoter Prediction and Inter-genomic Comparison: an Evo-Devo Study [PDF]

, 2010
Homeobox genes direct the anterior-posterior axis of the body plan in eukaryotic organisms. Promoter regions upstream of the Hox genes jumpstart the transcription process.
Co, E. L. (Elisa), Deocaris, C. C. (Custer), Endriga, M. A. (Maria), Paz, V. K. (Victoria), Sazon, J. M. (Jezreel)   +4 more
core  

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Gene prediction in eukaryotes with a generalized hidden Markov model that uses hints from external sources

BMC Bioinformatics, 2006
BackgroundIn order to improve gene prediction, extrinsic evidence on the gene structure can be collected from various sources of information such as genome-genome comparisons and EST and protein alignments.
M. Stanke, Oliver Schöffmann, B. Morgenstern, S. Waack   +3 more
semanticscholar   +1 more source

Inferring spatial and signaling relationships between cells from single cell transcriptomic data. [PDF]

, 2020
Single-cell RNA sequencing (scRNA-seq) provides details for individual cells; however, crucial spatial information is often lost. We present SpaOTsc, a method relying on structured optimal transport to recover spatial properties of scRNA-seq data by ...
Cang, Zixuan, Nie, Qing
core  

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Genome Sequencing and Comparative Genomic Analysis of Attenuated Strain Gibellulopsis nigrescens GnVn.1 Causing Mild Wilt in Sunflower

Journal of Fungi
Gibellulopsis nigrescens, previously classified in the Verticillium genus until 2007, is an attenuated pathogen known to provide cross-protection against Verticillium wilt in various crops.
Baozhu Dong, Wanyou Liu, Yingjie Zhao, Wei Quan, Lijun Hao, Dong Wang, Hongyou Zhou, Mingmin Zhao, Jianxiu Hao   +8 more
doaj   +1 more source

Consideration of non-canonical splice sites improves gene prediction on the Arabidopsis thaliana Niederzenz-1 genome sequence

BMC Research Notes, 2017
ObjectiveThe Arabidopsis thaliana Niederzenz-1 genome sequence was recently published with an ab initio gene prediction. In depth analysis of the predicted gene set revealed some errors involving genes with non-canonical splice sites in their introns ...
Boas Pucker, Daniela Holtgräwe, B. Weisshaar   +2 more
semanticscholar   +1 more source

The pause-initiation limit restricts transcription activation in human cells.

, 2019
Eukaryotic gene transcription is often controlled at the level of RNA polymerase II (Pol II) pausing in the promoter-proximal region. Pausing Pol II limits the frequency of transcription initiation ('pause-initiation limit'), predicting that the pause ...
Cramer, P., Gressel, S., Schwalb, B.
core   +1 more source

Plasmodium falciparum gametogenesis essential protein 1 (GEP1) is a transmission‐blocking target

FEBS Letters, EarlyView.
This study shows Plasmodium falciparum GEP1 is vital for activating sexual stages of malarial parasites even independently of a mosquito factor. Knockout parasites completely fail gamete formation even when a phosphodiesterase inhibitor is added. Two single‐nucleotide polymorphisms (V241L and S263P) are found in 12%–20% of field samples.
Frederik Huppertz, Milagros Siebeck Caturelli, Lina S. Lehmann, Florian Kurth, Alexander G. Maier, Kai Matuschewski   +5 more
wiley   +1 more source

Biological disturbance of MiR-425 and its application prospects in cardiovascular diseases

Frontiers in Cell and Developmental Biology
MiR-425 is a biological molecule that has potential applications in cardiovascular diseases. It can regulate biological functions by combining with LncRNAs, binding with proteins, and changing the differentiation of immune cells.
Shan Zhou, Bo Han, Bo Han
doaj   +1 more source