Results 141 to 150 of about 9,695,054 (384)

Genome Sequencing and Comparative Genomic Analysis of Attenuated Strain Gibellulopsis nigrescens GnVn.1 Causing Mild Wilt in Sunflower

Journal of Fungi
Gibellulopsis nigrescens, previously classified in the Verticillium genus until 2007, is an attenuated pathogen known to provide cross-protection against Verticillium wilt in various crops.
Baozhu Dong, Wanyou Liu, Yingjie Zhao, Wei Quan, Lijun Hao, Dong Wang, Hongyou Zhou, Mingmin Zhao, Jianxiu Hao   +8 more
doaj   +1 more source

Short-read reading-frame predictors are not created equal: sequence error causes loss of signal

BMC Bioinformatics, 2012
Background Gene prediction algorithms (or gene callers) are an essential tool for analyzing shotgun nucleic acid sequence data. Gene prediction is a ubiquitous step in sequence analysis pipelines; it reduces the volume of data by identifying the most ...
Trimble William L, Keegan Kevin P, D’Souza Mark, Wilke Andreas, Wilkening Jared, Gilbert Jack, Meyer Folker   +6 more
doaj   +1 more source

Patient-specific driver gene prediction and risk assessment through integrated network analysis of cancer omics profiles

Nucleic Acids Research, 2015
Extensive and multi-dimensional data sets generated from recent cancer omics profiling projects have presented new challenges and opportunities for unraveling the complexity of cancer genome landscapes. In particular, distinguishing the unique complement
D. Bertrand, Kern Rei Chng, F. G. Sherbaf, Anja Kiesel, B. Chia, Y. Sia, S. Huang, D. Hoon, E. Liu, A. Hillmer, N. Nagarajan   +10 more
semanticscholar   +1 more source

Circulating tumor cells in metastatic breast cancer patients treated with immune checkpoint inhibitors – a biomarker analysis of the ALICE and ICON trials

Molecular Oncology, EarlyView.
In this explorative biomarker analysis, we assessed serial sampling of circulating tumor cells (CTCs) with CellSearch in two randomized trials testing immune checkpoint inhibitors (ICIs) in metastatic breast cancer. Our data demonstrate a prognostic potential of CTCs, most apparent 4 weeks into ICI therapy.
Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Elin Borgen, Cecilie Bendigtsen Schirmer, Bjørnar Gilje, Øystein Garred, Jon Lømo, Marius Stensland, Oddmund Nordgård, Ragnhild Sørum Falk, Randi R. Mathiesen, Hege G. Russnes, Jon Amund Kyte, Bjørn Naume   +13 more
wiley   +1 more source

Biological disturbance of MiR-425 and its application prospects in cardiovascular diseases

Frontiers in Cell and Developmental Biology
MiR-425 is a biological molecule that has potential applications in cardiovascular diseases. It can regulate biological functions by combining with LncRNAs, binding with proteins, and changing the differentiation of immune cells.
Shan Zhou, Bo Han, Bo Han
doaj   +1 more source

Circulating tumor cells: advancing personalized therapy in small cell lung cancer patients

Molecular Oncology, EarlyView.
Small cell lung cancer (SCLC) is an aggressive form of lung cancer that spreads rapidly to secondary sites such as the brain and liver. Cancer cells circulating in the blood, “circulating tumor cells” (CTCs), have demonstrated prognostic value in SCLC, and evaluating biomarkers on CTCs could guide treatment decisions such as for PARP inhibitors ...
Prajwol Shrestha, Steven Kao, Veronica K. Cheung, Wendy A. Cooper, Nico van Zandwijk, John E. J. Rasko, Dannel Yeo   +6 more
wiley   +1 more source

Marker Haplotype Construction for the Hybrid Necrosis Gene Ne2 and Its Distribution in Old and New Wheat Varieties

Crops
Hybrid necrosis in wheat is caused by an interaction between two genes, Ne1 and Ne2, that triggers the gradual death of plant tissue. This trait affects wheat breeding as the gene Ne2 is the same as the gene Lr13 for leaf rust resistance. We have built a
Volker Mohler, Adalbert Bund, Lorenz Hartl, Theresa Albrecht   +3 more
doaj   +1 more source

Combining gene prediction methods to improve metagenomic gene annotation

BMC Bioinformatics, 2011
Background Traditional gene annotation methods rely on characteristics that may not be available in short reads generated from next generation technology, resulting in suboptimal performance for metagenomic (environmental) samples.
Rosen Gail L, Yok Non G
doaj   +1 more source

Gene prediction in eukaryotes with a generalized hidden Markov model that uses hints from external sources

BMC Bioinformatics, 2006
BackgroundIn order to improve gene prediction, extrinsic evidence on the gene structure can be collected from various sources of information such as genome-genome comparisons and EST and protein alignments.
M. Stanke, Oliver Schöffmann, B. Morgenstern, S. Waack   +3 more
semanticscholar   +1 more source

A comparative study of circulating tumor cell isolation and enumeration technologies in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells were spiked into donor blood to evaluate the recovery rates of the following circulating tumor cell (CTC) enrichment technologies: CellMag™, EasySep™, RosetteSep™, Parsortix® PR1, and Parsortix® Prototype systems. Each method's advantages and disadvantages are described.
Volga M Saini, Ezgi Oner, Mark P. Ward, Sinead Hurley, Brian David Henderson, Faye Lewis, Stephen P. Finn, Gerard J. Fitzmaurice, John J. O'Leary, Sharon O'Toole, Lorraine O'Driscoll, Kathy Gately   +11 more
wiley   +1 more source