Results 331 to 340 of about 9,911,867 (381)

Expert consensus on research paradigms and technological layout for clinical priority diseases in traditional Chinese medicine: Rheumatoid arthritis

Advanced Chinese Medicine, EarlyView.
Abstract Rheumatoid arthritis (RA) is a chronic, highly disabling autoimmune disease. Although modern medical treatments have made progress, challenges such as suboptimal efficacy, relapse, difficulties in comorbidity management, and side effects persist.
Dier Jin, Jinping Wang, Zihan Wang, Mei Mo, Xiaojing Liu, Nan Zhang, Xiaoxiao Zhang, Qingwen Tao, Yuan Xu   +8 more
wiley   +1 more source

Durable B‐Cell Impairment While Sparing IgA B Cells After Ocrelizumab Therapy in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Ocrelizumab (OCR), a humanized anti‐CD20 monoclonal antibody, is highly efficient in relapsing–remitting multiple sclerosis (RR‐MS). We assessed early cellular B‐cell profiles in patients prior to OCR treatment, on OCR treatment, and after 15 months of therapy discontinuation.
Alexandra Garcia, Stephane Rodriguez, Emilie Dugast, Christine Lebrun‐Frenay, Eric Thouvenot, Jérôme de Sèze, Emmanuelle Le Page, Sandra Vukusic, Inès Doghri, Eric Berger, Olivier Casez, Pierre Labauge, Aurélie Ruet, Catarina Raposo, Fabienne Le Frère, Arnaud B. Nicot, Sandrine Wiertlewski, Pierre‐Antoine Gourraud, Laure Michel, Laureline Berthelot, David‐Axel Laplaud   +20 more
wiley   +1 more source

Central Dysmyelination in SSADH‐Deficient Humans and Mice

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Succinic semialdehyde dehydrogenase deficiency (SSADHD) is an inherited metabolic disorder characterized by an accumulation of γ‐aminobutyric (GABA). In addition to its synaptic role as an inhibitory neurotransmitter, GABA also plays an important role in myelination.
Itay Tokatly Latzer, Henry H. C. Lee, Edward Yang, Cesar Alves, Mariarita Bertoldi, Caitlyn Fung, Spencer V. Steele, Eren Kule, Zijie Jin, Alexander Rotenberg, Jean‐Baptiste Roullet, Phillip L. Pearl   +11 more
wiley   +1 more source

Some of the next articles are maybe not open access.

Related searches:

NIDM: network impulsive dynamics on multiplex biological network for disease-gene prediction

Briefings Bioinform., 2021
The prediction of genes related to diseases is important to the study of the diseases due to high cost and time consumption of biological experiments. Network propagation is a popular strategy for disease-gene prediction.
Ju Xiang, Jiashuai Zhang, Ruiqing Zheng, Xingyi Li, Min Li   +4 more
semanticscholar   +1 more source

Vertebrate gene predictions and the problem of large genes [PDF]

Nature Reviews Genetics, 2003
To find unknown protein-coding genes, annotation pipelines use a combination of ab initio gene prediction and similarity to experimentally confirmed genes or proteins. Here, we show that although the ab initio predictions have an intrinsically high false-positive rate, they also have a consistently low false-negative rate.
Jun Yu, Jun Yu, Jun Yu, Yong Zhang, Yong Zhang, Zhao Xu, Hongkun Zheng, Jun Wang, Jun Wang, Shengting Li, Jia Ye, Gane Ka-Shu Wong, Gane Ka-Shu Wong, Gane Ka-Shu Wong   +13 more
openaire   +4 more sources

Machine learning-based approaches for disease gene prediction.

Briefings in Functional Genomics, 2020
Disease gene prediction is an essential issue in biomedical research. In the early days, annotation-based approaches were proposed for this problem. With the development of high-throughput technologies, interaction data between genes/proteins have grown ...
Duc-Hau Le
semanticscholar   +1 more source

Prediction of gene structure

Journal of Molecular Biology, 1992
We have developed a hierarchical rule base system for identifying genes in DNA sequences. Atomic sites (such as initiation codons, stop codons, acceptor sites and donor sites) are identified by a number of different methods and evaluated by a set of filters and rules chosen to maximize sensitivity; these are combined into higher-order gene elements ...
Temple F. Smith, Steen Knudsen, Neil Drake, Roderic Guigó   +3 more
openaire   +3 more sources

Gene Prediction

2013
International ...
Nicolas, Pierre, Chiapello, Hélène
openaire   +2 more sources

Gene prediction system

2008 International Symposium on Information Technology, 2008
With the increasingly popularity of genome sequencing, transforming such raw sequence data into knowledge remains a hard task. This project will develop an application for gene prediction using development tools such as Perl and PHP. The project will identify stretches of sequence for genomic DNA that is biologically functional including protein coding
Hazrina Yusof Hamdani, Siti Rohkmah Mohd Shukri   +1 more
openaire   +2 more sources