Results 31 to 40 of about 563,010 (309)

Predicting Gene Expression from Sequence [PDF]

Cell, 2004
We describe a systematic genome-wide approach for learning the complex combinatorial code underlying gene expression. Our probabilistic approach identifies local DNA-sequence elements and the positional and combinatorial constraints that determine their context-dependent role in transcriptional regulation.
Beer, Michael A., Tavazoie, Saeed
openaire   +2 more sources

Gene therapy: progress and predictions [PDF]

Proceedings of the Royal Society B: Biological Sciences, 2015
The first clinical gene delivery, which involved insertion of a marker gene into lymphocytes from cancer patients, was published 25 years ago. In this review, we describe progress since then in gene therapy. Patients with some inherited single-gene defects can now be treated with their own bone marrow stem cells that have been engineered with a viral ...
Collins, Mary, Thrasher, Adrian
openaire   +2 more sources

Analysis of Data Complexity in Human DNA for Gene-Containing Zone Prediction

Entropy, 2015
This study delves further into the analysis of genomic data by computing a variety of complexity measures. We analyze the effect of window size and evaluate the precision and recall of the prediction of gene zones, aided with a much larger dataset (full ...
Ricardo E. Monge, Juan L. Crespo
doaj   +1 more source

Predicting brain-disorder risk genes [PDF]

Nature Methods, 2020
H-MAGMA leverages chromatin interaction data to interpret GWAS results for brain disorders.
openaire   +2 more sources

Gene structure conservation aids similarity based gene prediction [PDF]

Nucleic Acids Research, 2004
One of the primary tasks in deciphering the functional contents of a newly sequenced genome is the identification of its protein coding genes. Existing computational methods for gene prediction include ab initio methods which use the DNA sequence itself as the only source of information, comparative methods using multiple genomic sequences, and ...
Irmtraud M, Meyer, Richard, Durbin
openaire   +2 more sources

Sickle Cell Disease Is an Inherent Risk for Asthma in a Sibling Comparison Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction Sickle cell disease (SCD) and asthma share a complex relationship. Although estimates vary, asthma prevalence in children with SCD is believed to be comparable to or higher than the general population. Determining whether SCD confers an increased risk for asthma remains challenging due to overlapping symptoms and the ...
Suhei C. Zuleta De Bernardis, Okeleji Olayinka, Mariam Z. Quraishi, Lakshmi V. Srivaths, Deborah L. Brown, Neethu M. Menon, Ricardo A. Mosquera, Ashwin P. Patel, James M. Stark, Aravind Yadav   +9 more
wiley   +1 more source

Controversies in modern evolutionary biology: the imperative for error detection and quality control

BMC Genomics, 2012
Background The data from high throughput genomics technologies provide unique opportunities for studies of complex biological systems, but also pose many new challenges.
Prosdocimi Francisco, Linard Benjamin, Pontarotti Pierre, Poch Olivier, Thompson Julie D   +4 more
doaj   +1 more source

PREDICTING GENE FUNCTION FROM GENE EXPRESSIONS AND ONTOLOGIES [PDF]

Biocomputing 2001, 2000
We introduce a methodology for inducing predictive rule models for functional classification of gene expressions from microarray hybridisation experiments. The basic learning method is the rough set framework for rule induction. The methodology is different from the commonly used unsupervised clustering approaches in that it exploits background ...
T R, Hvidsten, J, Komorowski, A K, Sandvik, A, Laegreid   +3 more
openaire   +2 more sources

Psychosocial Outcomes in Patients With Endocrine Tumor Syndromes: A Systematic Review

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction The combination of disease manifestations, the familial burden, and varying penetrance of endocrine tumor syndromes (ETSs) is unique. This review aimed to portray and summarize available data on psychosocial outcomes in patients with ETSs and explore gaps and opportunities for future research and care.
Daniël Zwerus, Floortje Strobbe, Annemarie A. Verrijn Stuart, Hanneke M. van Santen, Gerlof D. Valk, Sasja A. Schepers, Rachel S. van Leeuwaarde   +6 more
wiley   +1 more source

Stereotactic Body Radiation Therapy for Pediatric, Adolescent, and Young Adult Patients With Osteosarcoma: Local Control Outcomes With Dosimetric Analysis

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background/Objectives Osteosarcoma is a radioresistant tumor that may benefit from stereotactic body radiation therapy (SBRT) for locoregional control in metastatic/recurrent disease. We report institutional practice patterns, outcomes, toxicity, and failures in osteosarcoma patients treated with SBRT.
Jenna Kocsis, Shauna R. Campbell, Jonathan Jang, Eashwar Somasundaram, Chandana A. Reddy, Jacob G. Scott, Lilyana Angelov, Peter M. Anderson, Matteo Trucco, Zachary Burke, Lukas Nystrom, Nathan Mesko, Anthony Magnelli, Erin S. Murphy   +13 more
wiley   +1 more source