Results 61 to 70 of about 9,695,054 (384)

Research on the Computational Prediction of Essential Genes [PDF]

Frontiers in Cell and Developmental Biology, 2021
Genes, the nucleotide sequences that encode a polypeptide chain or functional RNA, are the basic genetic unit controlling biological traits. They are the guarantee of the basic structures and functions in organisms, and they store information related to biological factors and processes such as blood type, gestation, growth, and apoptosis.
Yuxin Guo, Yuxin Guo, Yuxin Guo, Yuxin Guo, Ying Ju, Dong Chen, Lihong Wang   +6 more
openaire   +3 more sources

Accurate prediction of gene feedback circuit behavior from component properties [PDF]

, 2007
A basic assumption underlying synthetic biology is that analysis of genetic circuit elements, such as regulatory proteins and promoters, can be used to understand and predict the behavior of circuits containing those elements. To test this assumption, we
Alon U, Jonathan W Young, Michael B Elowitz, Nitzan Rosenfeld, Peter S Swain, Ptashne M, Uri Alon   +6 more
core   +2 more sources

eggNOG-mapper v2: Functional Annotation, Orthology Assignments, and Domain Prediction at the Metagenomic Scale

bioRxiv, 2021
Even though automated functional annotation of genes represents a fundamental step in most genomic and metagenomic workflows, it remains challenging at large scales.
C. Cantalapiedra, Ana Hernández-Plaza, Ivica Letunic, P. Bork, J. Huerta-Cepas   +4 more
semanticscholar   +1 more source

Mining phenotypes for gene function prediction [PDF]

BMC Bioinformatics, 2008
Health and disease of organisms are reflected in their phenotypes. Often, a genetic component to a disease is discovered only after clearly defining its phenotype. In the past years, many technologies to systematically generate phenotypes in a high-throughput manner, such as RNA interference or gene knock-out, have been developed and used to decipher ...
Philip Groth, Philip Groth, Hans-Dieter Pohlenz, Bertram Weiss, Ulf Leser   +4 more
openaire   +3 more sources

Prediction of photoperiodic regulators from quantitative gene circuit models [PDF]

, 2004
Photoperiod sensors allow physiological adaptation to the changing seasons. The external coincidence hypothesis postulates that a light-responsive regulator is modulated by a circadian rhythm.
A Waring, AJ Laubsch, AM Santomero, AM Santomero, Bank for International Settlements (BIS, Bank of International Settlement, Basle Committee on Banking Supervision, C Bulter, C Culp, C Marshall, Capital Markets Risk Advisers, D Chew, D Silverman, F Stambaugh, GA Ferguson, GN Allport, J Berkowitz, J Bessis, J Boudoukh, J Engel, JF Sinkey, JM Mulvey, JP Bouchaud, JP Morgan, K Cuthbertson, K Dowd, K Dowd, K Thygerson, M Prisker, M Sarma, M Saunders, MCS Wong, MM Cornett, P Christoffersen, P Hague, P Jorion, PD Zecker, PR Dickson, RF Engle, S Heffernn, S Siegel, Stenhouse, Alexander & Co, TS Beder, W Härdle   +43 more
core   +1 more source

Algebraic shortcuts for leave-one-out cross-validation in supervised network inference [PDF]

, 2020
Supervised machine learning techniques have traditionally been very successful at reconstructing biological networks, such as protein-ligand interaction, protein-protein interaction and gene regulatory networks.
Airola, Antti, De Baets, Bernard, Pahikkala, Tapio, Stock, Michiel, Waegeman, Willem   +4 more
core   +1 more source

Analysis of Data Complexity in Human DNA for Gene-Containing Zone Prediction

Entropy, 2015
This study delves further into the analysis of genomic data by computing a variety of complexity measures. We analyze the effect of window size and evaluate the precision and recall of the prediction of gene zones, aided with a much larger dataset (full ...
Ricardo E. Monge, Juan L. Crespo
doaj   +1 more source

Decoding transcription and microRNA-mediated translation control in Drosophila development [PDF]

, 2010
The spatio-temporal regulation of gene expression lies at the heart of animal development. In this article we present an overview of our recent work to apply systems biological approaches to the study of transcription and microRNA-mediated translation ...
Gaul, Ulrike
core   +1 more source

HerGePred: Heterogeneous Network Embedding Representation for Disease Gene Prediction

IEEE journal of biomedical and health informatics, 2019
The discovery of disease-causing genes is a critical step towards understanding the nature of a disease and determining a possible cure for it. In recent years, many computational methods to identify disease genes have been proposed. However, making full
Kuo Yang, Ruyu Wang, Guangming Liu, Zixin Shu, Ning Wang, Runshun Zhang, Jian Yu, Jianxin Chen, Xiaodong Li, Xuezhong Zhou   +9 more
semanticscholar   +1 more source

Measuring the impact of gene prediction on gene loss estimates in Eukaryotes by quantifying falsely inferred absences

PLoS Comput. Biol., 2019
In recent years it became clear that in eukaryotic genome evolution gene loss is prevalent over gene gain. However, the absence of genes in an annotated genome is not always equivalent to the loss of genes.
E. S. Deutekom, Julian Vosseberg, Teunis J. P. van Dam, B. Snel   +3 more
semanticscholar   +1 more source