Results 251 to 260 of about 6,798,395 (302)
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RSPO2 gene rearrangement: a powerful driver of β-catenin activation in liver tumours
Gut, 2019Objective We aimed at the identification of genetic alterations that may functionally substitute for CTNNB1 mutation in ß-catenin-activated hepatocellular adenomas (HCAs) and hepatocellular carcinoma (HCC).
T. Longerich +21 more
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The arrangement and rearrangement of antibody genes
Nature, 1978Cloned segments of mouse chromosomal DNA provide direct evidence for the somatic rearrangement of kappa variable and constant region genes in antibody producing cells. This rearrangement apparently affects only one member of an allelic pair of light chain genes.
Seidman, J G, Leder, P
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Gene Rearrangements and T-Cell Lymphomas
Archives of Dermatology, 1993Cutaneous T-cell lymphomas comprise a broad spectrum of neoplasia ranging from indolent to highly aggressive types. To determine subset lineage and malignant vs benign nature, morphologic analysis, immunophenotyping, and flow cytometry have been used. However, given the shortcomings of these methods, molecular genetic techniques, which take particular ...
Margaret H. Terhune, Kevin D. Cooper
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Gene rearrangement and the generation of diversity [PDF]
Nature, 1982 THE eukaryotic genome has rececently begun to seem less stable, both in evolution1 and in ontogeny2, than many biologists had assumed. These trends prompted the Institute of Genetics to invite to its annual Spring meeting* speakers on six genetically labile systems: the MHC locus and the immunoglobulin genes of mammals, the genes encoding the surface ...
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Antigen receptor gene rearrangement
Current Opinion in Immunology, 1998Two specialized forms of site-directed double-strand (ds) DNA breakage and rejoining are part of the physiologic program of lymphocytes. One is recombination of the V, D and J gene sequences, termed V(D)J recombination, occurring during early B- and T-cell development, and the other is class-switch recombination occurring exclusively in mature B cells.
Michael R. Lieber +2 more
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Gene Rearrangements in Lymphoma
The American Journal of Dermatopathology, 1987Clonality is regarded as an important diagnostic feature of B-cell lymphomas, but until recently the clonality of T-cell proliferations could not be directly determined. Elucidation of the genetic events in lymphocytic differentiation has led to the development of an assay for clonality in both B- and T-cell infiltrates.
Philip E. LeBoit, Tristram G. Parslow
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2012
The B- and T-cell gene rearrangement test is one of the hallmarks of the molecular pathology diagnostic laboratories. Historically done with Southern blot and now adopted by many laboratories using PCR, the test is used as an aid in pathology diagnosis to distinguish between benign lymphoproliferative disorders, usually polyclonal, and clonally derived
Rizwan Naeem, Siby Sebastian, Juan Du
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The B- and T-cell gene rearrangement test is one of the hallmarks of the molecular pathology diagnostic laboratories. Historically done with Southern blot and now adopted by many laboratories using PCR, the test is used as an aid in pathology diagnosis to distinguish between benign lymphoproliferative disorders, usually polyclonal, and clonally derived
Rizwan Naeem, Siby Sebastian, Juan Du
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Gene rearrangements in malignant lymphomas
1993Diagnosis and classification of malignant lymphomas is one of the most difficult and challenging problems encountered by pathologists today. Techniques for molecular genetic analysis have added an entirely new dimension to our understanding of the biology of the normal immune response.
Rita M. Braziel, Allan R. Sacker
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Gene rearrangements in T-cell lymphoblastic lymphoma
The Journal of Pathology, 1999This study presents an examination of the Ig heavy chain (IgH) and T-cell receptor gamma (TCRgamma) genes in a series of 39 CD3-positive T-cell acute lymphoblastic leukaemia (ALL) cases with and without co-expression of CD79a; 30/39 cases had a rearrangement of the TCRgamma genes and two of these 30 cases also demonstrated an IgH rearrangement.
Pilozzi E. +6 more
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The rearrangements of immunoglobulin genes
Trends in Biochemical Sciences, 1981Abstract Antibodies are encoded by a complex gene system that apparently undergoes unprecedented rearrangements during lymphocyte development. The immunoglobulin gene system has evolved novel and flexible strategies for dealing with large amounts of genetic information.
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