Results 261 to 270 of about 268,817 (310)
Some of the next articles are maybe not open access.
2012
The B- and T-cell gene rearrangement test is one of the hallmarks of the molecular pathology diagnostic laboratories. Historically done with Southern blot and now adopted by many laboratories using PCR, the test is used as an aid in pathology diagnosis to distinguish between benign lymphoproliferative disorders, usually polyclonal, and clonally derived
Rizwan Naeem, Siby Sebastian, Juan Du
openaire +2 more sources
The B- and T-cell gene rearrangement test is one of the hallmarks of the molecular pathology diagnostic laboratories. Historically done with Southern blot and now adopted by many laboratories using PCR, the test is used as an aid in pathology diagnosis to distinguish between benign lymphoproliferative disorders, usually polyclonal, and clonally derived
Rizwan Naeem, Siby Sebastian, Juan Du
openaire +2 more sources
Gene rearrangements in malignant lymphomas
1993Diagnosis and classification of malignant lymphomas is one of the most difficult and challenging problems encountered by pathologists today. Techniques for molecular genetic analysis have added an entirely new dimension to our understanding of the biology of the normal immune response.
Rita M. Braziel, Allan R. Sacker
openaire +3 more sources
Gene rearrangements in T-cell lymphoblastic lymphoma
The Journal of Pathology, 1999This study presents an examination of the Ig heavy chain (IgH) and T-cell receptor gamma (TCRgamma) genes in a series of 39 CD3-positive T-cell acute lymphoblastic leukaemia (ALL) cases with and without co-expression of CD79a; 30/39 cases had a rearrangement of the TCRgamma genes and two of these 30 cases also demonstrated an IgH rearrangement.
Pilozzi E. +6 more
openaire +5 more sources
The rearrangements of immunoglobulin genes
Trends in Biochemical Sciences, 1981Abstract Antibodies are encoded by a complex gene system that apparently undergoes unprecedented rearrangements during lymphocyte development. The immunoglobulin gene system has evolved novel and flexible strategies for dealing with large amounts of genetic information.
openaire +2 more sources
The Role of Gene Rearrangement in Evolution
1979Chromosomes are commonly regarded as conservative structures, in which an exact amount of genetic information is arranged in a definite sequential order. This order is normally preserved when information is exchanged between chromosomes, and guaranteed by a set of recombination enzymes that function only with paired sectors of homologous DNA.
H. Saedler, P. Nevers, D. Ghosal
openaire +3 more sources
Epigenetic control of Tcrb gene rearrangement
Seminars in Immunology, 2010V(D)J recombination assembles antigen receptor genes from germline V, D and J segments during lymphocyte development. In αβT-cells, this leads to the subsequent expression of T-cell receptor (TCR) β and α chains. Generally, V(D)J recombination is closely controlled at various levels, including cell-type and cell-stage specificities, order of locus/gene
Salvatore Spicuglia +6 more
openaire +4 more sources
The variability, arrangement, and rearrangement of immunoglobulin genes
Canadian Journal of Biochemistry, 1980The multiplicity of heavy-chain variable-region (VH) genes in mouse and human DNA has been estimated using a mouse heavy- (H) chain cDNA clone. We found about 10 hybridization components in mouse DNA and about 20 components in human DNA. Cross-hybridization studies of variable region (V) genes indicate that these components represent the numbers of ...
Pamela Hamlyn +3 more
openaire +3 more sources
Gene rearrangement analysis in lymphoid neoplasia
Clinics in Dermatology, 1991Current uses for gene rearrangement analysis in clinical dermatology are listed in Table 3. This technique is useful for determining the existence of clonal populations within a background of polyclonal lymphoid cells; therefore, it is helpful in the diagnosis and staging of patients with CTCL and PTCL.
Margot S. Peters +2 more
openaire +3 more sources
Excision products of immunoglobulin gene rearrangements
Immunology Letters, 1989We have isolated circular DNAs from splenocytes of euthymic and athymic mice, and prepared the DNA libraries of 1.5 X 10(6) clones. Hundreds of clones homologous to immunoglobulin (Ig) heavy chain segments (DSP2 and DQ52-JH) or light chain segments (J kappa and J lambda) have been identified.
Toshiyasu Hirama +3 more
openaire +3 more sources
Understanding patterns of immunoglobulin gene rearrangements
Seminars in Immunology, 1994When immunoglobulin (Ig) gene rearrangements are analyzed, several patterns emerge. The rearrangements at the various loci generally appear in a specific temporal order. In addition, within a given locus the frequency of rearrangement of the various gene segments is not equal but is skewed towards preferential rearrangement of particular gene segments.
Aaron J. Marshall +4 more
openaire +3 more sources