Results 261 to 270 of about 6,798,395 (302)

The Role of Gene Rearrangement in Evolution

1979
Chromosomes are commonly regarded as conservative structures, in which an exact amount of genetic information is arranged in a definite sequential order. This order is normally preserved when information is exchanged between chromosomes, and guaranteed by a set of recombination enzymes that function only with paired sectors of homologous DNA.
H. Saedler, P. Nevers, D. Ghosal
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Epigenetic control of Tcrb gene rearrangement

Seminars in Immunology, 2010
V(D)J recombination assembles antigen receptor genes from germline V, D and J segments during lymphocyte development. In αβT-cells, this leads to the subsequent expression of T-cell receptor (TCR) β and α chains. Generally, V(D)J recombination is closely controlled at various levels, including cell-type and cell-stage specificities, order of locus/gene
Salvatore Spicuglia, Aleksandra Pekowska, Aleksandra Pekowska, Pierre Ferrier, Pierre Ferrier, Joaquin Zacarias-Cabeza, Joaquin Zacarias-Cabeza   +6 more
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The variability, arrangement, and rearrangement of immunoglobulin genes

Canadian Journal of Biochemistry, 1980
The multiplicity of heavy-chain variable-region (VH) genes in mouse and human DNA has been estimated using a mouse heavy- (H) chain cDNA clone. We found about 10 hybridization components in mouse DNA and about 20 components in human DNA. Cross-hybridization studies of variable region (V) genes indicate that these components represent the numbers of ...
Pamela Hamlyn, G Matthyssens, Terence H. Rabbitts, Bruce A. Roe   +3 more
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Gene rearrangement analysis in lymphoid neoplasia

Clinics in Dermatology, 1991
Current uses for gene rearrangement analysis in clinical dermatology are listed in Table 3. This technique is useful for determining the existence of clonal populations within a background of polyclonal lymphoid cells; therefore, it is helpful in the diagnosis and staging of patients with CTCL and PTCL.
Margot S. Peters, Brian D. Zelickson, Mark R. Pittelkow   +2 more
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Excision products of immunoglobulin gene rearrangements

Immunology Letters, 1989
We have isolated circular DNAs from splenocytes of euthymic and athymic mice, and prepared the DNA libraries of 1.5 X 10(6) clones. Hundreds of clones homologous to immunoglobulin (Ig) heavy chain segments (DSP2 and DQ52-JH) or light chain segments (J kappa and J lambda) have been identified.
Toshiyasu Hirama, Sunao Takeshita, Masaaki Toda, Hideo Yamagishi   +3 more
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Clinical activity of crizotinib in advanced non-small cell lung cancer (NSCLC) harboring ROS1 gene rearrangement.

, 2012
7508 Background: Chromosomal rearrangements of the ROS1 receptor tyrosine kinase gene define a new molecular subset of NSCLC. In cell lines, ROS1 rearrangements lead to expression of oncogenic ROS1 fusion kinases and sensitivity to ROS kinase inhibition.
A. Shaw, D. Camidge, J. Engelman, B. Solomon, E. Kwak, J. Clark, R. Salgia, G. Shapiro, Y. Bang, Weiwei Tan, L. Tye, K. Wilner, P. Stephenson, M. Varella-Garcia, K. Bergethon, A. Iafrate, S. Ou   +16 more
semanticscholar   +1 more source

Understanding patterns of immunoglobulin gene rearrangements

Seminars in Immunology, 1994
When immunoglobulin (Ig) gene rearrangements are analyzed, several patterns emerge. The rearrangements at the various loci generally appear in a specific temporal order. In addition, within a given locus the frequency of rearrangement of the various gene segments is not equal but is skewed towards preferential rearrangement of particular gene segments.
Aaron J. Marshall, Gillian E. Wu, Jacqueline Pennycook, Calvin C. K. Yu, Astrid Sollbach   +4 more
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Mesenchymal Tumors with EWSR1 Gene Rearrangements

Surgical Pathology Clinics, 2019
Among the various genes that can be rearranged in soft tissue neoplasms associated with nonrandom chromosomal translocations, EWSR1 is the most frequent one to partner with other genes to generate recurrent fusion genes. This leads to a spectrum of clinically and pathologically diverse mesenchymal and nonmesenchymal neoplasms, variably manifesting as ...
Cyril Fisher, Khin Thway
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Utility of Gene Rearrangements in Lymphoid Malignancies

Annual Review of Medicine, 1993
Molecular genetic study of lymphoid neoplasms by Southern blotting or polymerase chain reaction permits the ready detection of gene rearrangements. Clonal rearrangements of immunoglobulin and T-cell receptor genes identify neoplasms of B- and T-cell lineage, respectively. Additionally, lymphoma-specific chromosome translocations involving oncogenes are
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Regulation of immunoglobulin gene rearrangement and expression

Immunology Today, 1989
The molecular genetic events leading to Ig expression and their control formed the topic of a recent EMBO workshop. This report by Michael Taussig, Martin Sims and Ulrich Krawinkel discusses contributions dealing with genes expressed in early pre-B cells, the mechanism of rearrangement, aberrant rearrangements seen in B cells of SCID mice, the feedback
Martin J. Sims, Ulrich Krawinkel, Michael J. Taussig   +2 more
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