Results 111 to 120 of about 1,691,605 (342)
Cell, 2014 Reference EPFL-ARTICLE-198028doi:10.1016/j.cell.2014.01.060View record in Web of Science Record created on 2014-04-02, modified on 2017-05 ...
Denis Duboule +2 more
openaire +5 more sources
Molecular Oncology, EarlyView.Adaptive ERK reactivation hinders FLT3 tyrosine kinase inhibitor (TKI) treatment in FLT3/ITD acute myeloid leukemia. Here, we report that FLT3 TKI treatment rapidly induces AXL expression and upregulation that is temporally associated with the adaptive ERK reactivation.
Tessa S. Seale +9 more
wiley +1 more source
Single nucleotide polymorphisms that modulate microRNA regulation of gene expression in tumors [PDF]
arXiv, 2018 Genome-wide association studies (GWAS) have identified single nucleotide polymorphisms (SNPs) associated with trait diversity and disease susceptibility, yet the functional properties of many genetic variants and their molecular interactions remains unclear.
arxiv
Involvement of the relA gene product and feedback inhibition in the regulation of DUP-N-acetylmuramyl-peptide synthesis in Escherichia coli. [PDF]
, 1978 E E Ishiguro, William D. Ramey
openalex +1 more source
Molecular Oncology, EarlyView.The authors analyzed the spatial distributions of gene and metabolite profiles in cervical cancer through spatial transcriptomic and spatially resolved metabolomic techniques. Pivotal genes and metabolites within these cases were then identified and validated.
Lixiu Xu +3 more
wiley +1 more source
Structure of the Nipah virus polymerase phosphoprotein complex
Nature CommunicationsThe Nipah virus (NiV), a member of the Paramyxoviridae family, is notorious for its high fatality rate in humans. The RNA polymerase machinery of NiV, comprising the large protein L and the phosphoprotein P, is essential for viral replication. This study
Ge Yang, Dong Wang, Bin Liu
doaj +1 more source
Transcriptomic Causal Networks identified patterns of differential gene regulation in human brain from Schizophrenia cases versus controls [PDF]
arXiv, 2019 Common and complex traits are the consequence of the interaction and regulation of multiple genes simultaneously, which work in a coordinated way. However, the vast majority of studies focus on the differential expression of one individual gene at a time.
arxiv
Biotinyl 5'-adenylate: corepressor role in the regulation of the biotin genes of Escherichia coli K-12. [PDF]
, 1979 Om Prakash, M A Eisenberg
openalex +1 more source
Molecular Oncology, EarlyView.The authors applied joint/mixed models that predict mortality of trifluridine/tipiracil‐treated metastatic colorectal cancer patients based on circulating tumor DNA (ctDNA) trajectories. Patients at high risk of death could be spared aggressive therapy with the prospect of a higher quality of life in their remaining lifetime, whereas patients with a ...
Matthias Unseld +7 more
wiley +1 more source
A quantitative study of the benefits of co-regulation using the spoIIA operon as an example [PDF]
arXiv, 2006 The distribution of most genes is not random, and functionally linked genes are often found in clusters. Several theories have been put forward to explain the emergence and persistence of operons in bacteria. Careful analysis of genomic data favours the co-regulation model, where gene organization into operons is driven by the benefits of coordinated ...
arxiv