Results 121 to 130 of about 1,691,605 (342)

Mechanisms of regulation of cell-mediated immunity. IV. Azobenzenearsonate-specific suppressor factor(s) bear cross-reactive idiotypic determinants the expression of which is linked to the heavy-chain allotype linkage group of genes. [PDF]

, 1979
Bruce Allen Bach, M I Greene, Baruj Benacerraf, Alfred Nisonoff   +3 more
openalex   +1 more source

Integrative systems‐level analysis reveals a contextual crosstalk between hypoxia and global metabolism in human breast tumors

Molecular Oncology, EarlyView.
Breast tumor samples scored for metabolic deregulation (M1 to M3) were given a hypoxia score (HS). The highest HS occurred in patients with strongest metabolic deregulation (M3), supporting tumor aggressiveness. HS correlated with the highest number of metabolic pathways in M1. This suggests hypoxia to be an early event in metabolic deregulation.
Raefa Abou Khouzam, Salem Chouaib, Mohammad Askandar Iqbal   +2 more
wiley   +1 more source

A CUG codon-adapted anchor-away toolkit for functional analysis of genes in Candida albicans

mSphere
Promoter shutoff of essential genes in the diploid Candida albicans has often been insufficient to create tight, conditional null alleles due to leaky expression and has been a stumbling block in pathogenesis research.
Basharat Bashir Teli, Priyanka Nagar, Yumnam Priyadarshini, Poonam Poonia, Krishnamurthy Natarajan   +4 more
doaj   +1 more source

Integrative analysis of circulating tumor cells (CTCs) and exosomes from small‐cell lung cancer (SCLC) patients: a comprehensive approach

Molecular Oncology, EarlyView.
This study simultaneously investigated circulating tumor cells (CTCs) and exosomes from small‐cell lung cancer (SCLC) patients. The elevated expression of JUNB and CXCR4 in CTCs was a poor prognostic factor for SCLC patients, whereas exosomal overexpression of these biomarkers revealed a high discrimination ability of patients from healthy individuals,
Dimitrios Papakonstantinou, Argyro Roumeliotou, Evangelia Pantazaka, Athanasios‐Nasir Shaukat, Athina Christopoulou, Angelos Koutras, Foteinos‐Ioannis Dimitrakopoulos, Vassilis Georgoulias, Anastasia Xagara, Evangelia Chantzara, Fillipos Koinis, Athanasios Kotsakis, Constantinos Stathopoulos, Galatea Kallergi   +13 more
wiley   +1 more source

Her2 Ile655Val polymorphism and its association with breast cancer risk: an updated meta-analysis of case-control studies

Scientific Reports, 2018
Breast cancer (BC) is one of the most common types of cancer in women worldwide. Several factors including genetic and environmental have been linked with susceptibility to development of BC. Her2 is a transmembrane protein with tyrosine kinase activity,
B. Madhu Krishna, Sanjib Chaudhary, Aditya K. Panda, Dipti Ranjan Mishra, Sandip K. Mishra   +4 more
doaj   +1 more source

A model for cytoplasm-governed gene regulation [PDF]

, 1976
A. V. Lichtenstein, V. S. Shapot
openalex   +1 more source

The accumulation of myeloid‐derived suppressor cells participates in abdominal infection‐induced tumor progression through the PD‐L1/PD‐1 axis

Molecular Oncology, EarlyView.
This study explores how sepsis affects GC progression by creating an immunosuppressive environment. Our findings reveal that sepsis promotes immune dysregulation, enhancing tumor growth and metastasis. Targeting the PD‐1/PD‐L1 pathway with monoclonal antibodies shows potential for restoring immune function and improving outcomes in cancer patients ...
Yiding Wang, Ting Guo, Xiaofang Xing, Xijuan Liu, Xuejun Gan, Yingai Li, Yan Liu, Fei Shan, Zhouqiao Wu, Jiafu Ji, Ziyu Li   +10 more
wiley   +1 more source

Author Correction: Dynamic SUMO modification regulates mitotic chromosome assembly and cell cycle progression in Caenorhabditis elegans

Nature Communications, 2022
Federico Pelisch, Remi Sonneville, Ehsan Pourkarimi, Ana Agostinho, J. Julian Blow, Anton Gartner, Ronald T. Hay   +6 more
doaj   +1 more source

Landscapes and nonequilibrium fluctuations of eukaryotic gene regulation [PDF]

arXiv
Understanding the interplay among processes that occur over different timescales is a challenging issue in the physics of systems regulation. In gene regulation, the timescales for changes in chromatin states can differ from those for changes in the concentration of product protein, raising questions about how to understand their coupled dynamics.
arxiv  

Simian virus 40 gene A regulation of cellular DNA synthesis. I. In permissive cells [PDF]

, 1979
John Hiscott, Vittorio Defendi
openalex   +1 more source