Results 231 to 240 of about 2,989,814 (357)

Maternal diabetes disrupts early corticogenesis through altered mitotic gene regulation: a transcriptomic analysis. [PDF]

Front Endocrinol (Lausanne)
Valle-Bautista R, de la Merced-García DS, Díaz-Piña DA, Díaz NF, Ávila-González D, Molina-Hernández A.   +5 more
europepmc   +1 more source

Transcriptional control of herpesvirus gene expression: gene functions required for positive and negative regulation.

, 1986
Paul J. Godowski, David M. Knipe
openalex   +1 more source

Nitrogen regulation system of Klebsiella aerogenes: the nac gene [PDF]

, 1983
R A Bender, Peter M. Snyder, R Bueno, Marie Quinto, Boris Magasanik   +4 more
openalex   +1 more source

Loss of primary cilia promotes EphA2‐mediated endothelial‐to‐mesenchymal transition in the ovarian tumor microenvironment

Molecular Oncology, EarlyView.
Loss of primary cilia in endothelial cells promotes EndMT and vascular abnormalities in the ovarian tumor microenvironment through EphA2 activation. Using human samples, in vitro models, and endothelial‐specific Kif3a‐knockout mice, we show that primary cilia loss drives the acquisition of cancer‐associated fibroblast‐like phenotypes, thereby ...
Jin Gu Cho, Yubin Hah, Eunsik Yun, Hye In Ka, Aram Lee, Sora Han, Dawn Lee, Sung Wook Kim, Jong Hoon Park, Byung Su Kwon, Young Yang, Jongmin Kim   +11 more
wiley   +1 more source

From homogeneity to heterogeneity: Refining stochastic simulations of gene regulation. [PDF]

Comput Struct Biotechnol J
Chae SJ, Shin S, Lee K, Lee S, Kim JK.
europepmc   +1 more source

Evidence that the familial adenomatous polyposis gene is involved in a subset of colon cancers with a complementable defect in c-myc regulation. [PDF]

, 1989
M D Erisman, J. K. Scott, Susan M. Astrin   +2 more
openalex   +1 more source

Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma

Molecular Oncology, EarlyView.
GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski, Molly R. Danks, John P. Thomson, Morwenna Muir, Martin Lee, John C. Dawson, Ana T. Amaral, Juan Diaz‐Martin, David S. Moura, Javier Martin‐Broto, Ali Alsaadi, Donald M. Salter, Ailsa J. Oswald, Graeme Grimes, Larry Hayward, Ted R. Hupp, Karen Sisley, Paul H. Huang, Neil O. Carragher, Valerie G. Brunton   +19 more
wiley   +1 more source

The subcellular distribution of phosphorylated Y‐box‐binding protein‐1 at S102 in colorectal cancer patients, stratified by KRAS mutational status and clinicopathological features

Molecular Oncology, EarlyView.
This study identifies nuclear YB‐1 S102 phosphorylation as a marker associated with KRAS and FBXW7 mutations in colorectal cancer. Mutated KRAS correlates specifically with nuclear, not cytoplasmic, S102 YB‐1. These findings provide the first ex vivo evidence of this link in CRC and suggest future studies should assess the prognostic and therapeutic ...
Konstanze Lettau, Stephan Forchhammer, Birgit Fehrenbacher, Lejla Mahmutovic, Marcus Scharpf, Gunnar Blumenstock, Martin Schaller, Irina Bonzheim, Shayan Khozooei, Mahmoud Toulany   +9 more
wiley   +1 more source

Spatiotemporal transcriptomics reveals key gene regulation for grain yield and quality in wheat. [PDF]

Genome Biol
Li X, Wan Y, Wang D, Li X, Wu J, Xiao J, Chen K, Han X, Chen Y.   +8 more
europepmc   +1 more source

Polypeptide hormone regulation of gene expression. Thyrotropin-releasing hormone rapidly stimulates both transcription of the prolactin gene and the phosphorylation of a specific nuclear protein.

, 1983
Geoffrey Murdoch, Rodrigo Franco, Ronald M. Evans, M G Rosenfeld   +3 more
openalex   +1 more source