Results 231 to 240 of about 2,989,814 (357)

Maternal diabetes disrupts early corticogenesis through altered mitotic gene regulation: a transcriptomic analysis. [PDF]

open access: yesFront Endocrinol (Lausanne)
Valle-Bautista R   +5 more
europepmc   +1 more source

Nitrogen regulation system of Klebsiella aerogenes: the nac gene [PDF]

open access: bronze, 1983
R A Bender   +4 more
openalex   +1 more source

Loss of primary cilia promotes EphA2‐mediated endothelial‐to‐mesenchymal transition in the ovarian tumor microenvironment

open access: yesMolecular Oncology, EarlyView.
Loss of primary cilia in endothelial cells promotes EndMT and vascular abnormalities in the ovarian tumor microenvironment through EphA2 activation. Using human samples, in vitro models, and endothelial‐specific Kif3a‐knockout mice, we show that primary cilia loss drives the acquisition of cancer‐associated fibroblast‐like phenotypes, thereby ...
Jin Gu Cho   +11 more
wiley   +1 more source

From homogeneity to heterogeneity: Refining stochastic simulations of gene regulation. [PDF]

open access: yesComput Struct Biotechnol J
Chae SJ, Shin S, Lee K, Lee S, Kim JK.
europepmc   +1 more source

Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma

open access: yesMolecular Oncology, EarlyView.
GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski   +19 more
wiley   +1 more source

The subcellular distribution of phosphorylated Y‐box‐binding protein‐1 at S102 in colorectal cancer patients, stratified by KRAS mutational status and clinicopathological features

open access: yesMolecular Oncology, EarlyView.
This study identifies nuclear YB‐1 S102 phosphorylation as a marker associated with KRAS and FBXW7 mutations in colorectal cancer. Mutated KRAS correlates specifically with nuclear, not cytoplasmic, S102 YB‐1. These findings provide the first ex vivo evidence of this link in CRC and suggest future studies should assess the prognostic and therapeutic ...
Konstanze Lettau   +9 more
wiley   +1 more source

Spatiotemporal transcriptomics reveals key gene regulation for grain yield and quality in wheat. [PDF]

open access: yesGenome Biol
Li X   +8 more
europepmc   +1 more source

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