Results 291 to 300 of about 3,161,105 (354)

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Calcium starvation leads to strain-specific gene regulation of lipid and carotenoid production in Mucor circinelloides. [PDF]

G3 (Bethesda)
Baalsrud HT, Byrtusova D, To TH, Larsen IE, Bøe VA, Grønvold L, Fu J, Árnyasi M, Shapaval V, Sandve SR.   +9 more
europepmc   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Gene Regulation

Molecular Therapy, 2000
openaire   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

E2F1 K117 methylation by SETD6 disrupts BRD4-E2F1 binding and modulates E2F1 chromatin binding and gene regulation in prostate cancer cells. [PDF]

Nucleic Acids Res
Ulu GT, Kublanovsky M, Shalev R, Biton TE, Feldman M, Murr S, Brockmeyer J, Dorscht F, Weirich S, Levy D, Jeltsch A.   +10 more
europepmc   +1 more source

Computational methods for alternative polyadenylation and splicing in post-transcriptional gene regulation. [PDF]

Exp Mol Med
Fahmi NA, Saha S, Song Q, Lou Q, Yong J, Zhang W.   +5 more
europepmc   +1 more source

Reviewer #2 (Public Review): Coordinated regulation of gene expression in Plasmodium female gametocytes by two transcription factors

openalex   +1 more source

Diverse short tandem repeat sequences influence gene regulation in human populations. [PDF]

Genome Biol
Mitina A, Engchuan W, Trost B, Pellecchia G, Scherer SW, Yuen RKC.   +5 more
europepmc   +1 more source

Protocol for differentiation of vascular smooth muscle cells from human iPSCs and their application in CRISPRa-mediated gene regulation. [PDF]

STAR Protoc
Priesmeier L, Tiburcy M, Zelarayán LC.
europepmc   +1 more source