Results 161 to 170 of about 1,213,334 (312)
IS THE GENE THE UNIT OF SELECTION?
Genetics, 1970 I, Franklin, R C, Lewontin
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Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
AlgorithmsThis study presents a novel method, termed RBAVO-DE (Relief Binary African Vultures Optimization based on Differential Evolution), aimed at addressing the Gene Selection (GS) challenge in high-dimensional RNA-Seq data, specifically the rnaseqv2 ...
Mona G. Gafar +3 more
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Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Feature Selection via Coalitional Game Theory [PDF]
, 2007 We present and study the contribution-selection algorithm (CSA), a novel algorithm for feature selection. The algorithm is based on the multiperturbation shapley analysis (MSA), a framework that relies on game theory to estimate usefulness. The algorithm
Dror, G., Cohen, S. B., Ruppin, E.
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COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Selection, maternal effects and inbreeding in reindeer husbandry [PDF]
, 2003 In extensive grazing systems where several owners’ flocks are allowed to mix, selection strategies will also interact, due to gene flow between flocks. The aim of the thesis was to analyse breeding schemes in terms of genetic gain and rate of inbreeding (
Rönnegård, Lars
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Gene Selection Algorithms in a Single-Cell Gene Decision Space Based on Self-Information
MathematicsA critical step for gene selection algorithms using rough set theory is the establishment of a gene evaluation function to assess the classification ability of candidate gene subsets.
Yan Fang +3 more
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Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Associative memory in gene regulation networks [PDF]
, 2010 The pattern of gene expression in the phenotype of an organism is determined in part by the dynamical attractors of the organism’s gene regulation network.
Buckley, C. L. +3 more
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