Results 141 to 150 of about 1,213,334 (312)
Genealogy-based methods for inference of historical recombination and gene flow and their application in Saccharomyces cerevisiae [PDF]
, 2012 Genetic exchange between isolated populations, or introgression between species, serves as a key source of novel genetic material on which natural selection can act.
Brem, Rachel B. +11 more
core +1 more source
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
Gene expression programming approach to event selection in high energy physics [PDF]
, 2006 Gene Expression Programming is a new evolutionary algorithm that overcomes many limitations of the more established Genetic Algorithms and Genetic Programming. Its first application to high energy physics data analysis is presented.
Teodorescu, L
core +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Evidence for widespread degradation of gene control regions in hominid genomes. [PDF]
, 2005 Although sequences containing regulatory elements located close to protein-coding genes are often only weakly conserved during evolution, comparisons of rodent genomes have implied that these sequences are subject to some selective constraints ...
Peter D Keightley +8 more
core +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Balancing selection and its effects on sequences in nearby genome regions. [PDF]
, 2006 Our understanding of balancing selection is currently becoming greatly clarified by new sequence data being gathered from genes in which polymorphisms are known to be maintained by selection.
Deborah Charlesworth +2 more
core +1 more source
Gene selection with multiple ordering criteria
BMC Bioinformatics, 2007 Background A microarray study may select different differentially expressed gene sets because of different selection criteria. For example, the fold-change and p-value are two commonly known criteria to select differentially expressed genes under two ...
Tzeng ShengLi +3 more
doaj +1 more source
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Sequence variation, evolutionary constraint, and selection at the CD163 gene in pigs [PDF]
, 2018 BackgroundIn this work, we investigated sequence variation, evolutionary constraint, and selection at the CD163 gene in pigs. A functional CD163 protein is required for infection by porcine reproductive and respiratory syndrome virus, which is a serious ...
Johnsson, Martin, +1 more
core +1 more source