Results 131 to 140 of about 1,213,334 (312)
Phosphoinositides and inositol phosphates as molecular glues
FEBS Letters, EarlyView.Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry +9 more
wiley +1 more source
Experimental condition selection in whole-genome functional classification [PDF]
, 2004 Microarray technologies enable the quantitative simultaneously monitoring of expression levels for thousands of genes under various experimental conditions.
Wong, K.W. +3 more
core +1 more source
Selection on Alleles Affecting Human Longevity and Late-Life Disease: The Example of Apolipoprotein E [PDF]
, 2010 It is often claimed that genes affecting health in old age, such as cardiovascular and Alzheimer diseases, are beyond the reach of natural selection. We show in a simulation study based on known genetic (apolipoprotein E) and non-genetic risk factors ...
Kirkwood Thomas B. L. +5 more
core +1 more source
FEBS Letters, EarlyView.Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara +3 more
wiley +1 more source
Selection Does Not Operate Primarily on Genes [PDF]
, 2008 This chapter offers a review of standard views about the requirements for natural selection to shape evolution and for the sorts of ‘units’ on which selection might operate.
Burian, Richard
core
Models of cultural niche construction with selection and assortative mating [PDF]
, 2012 This research was supported in part by National Institutes of Health grant GM28016 and a Biotechnology and Biological Sciences Research Council studentship to LF. The funders had no role in study design, data collection and analysis, decision to publish,
Fogarty, Laurel +11 more
core +1 more source
Positive Selection on Mammalian Immune Genes—Effects of Gene Function and Selective Constraint
Molecular Biology and EvolutionAbstract Genome-wide analyses of various taxa have repeatedly shown that immune genes are important targets of positive selection. However, little is known about what factors determine which immune genes are under positive selection. To address this question, we here focus on the mammalian immune system and investigate the importance of ...
Mridula Nandakumar +3 more
openaire +3 more sources
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
Selection of reference genes for gene expression studies in rats
Journal of Biotechnology, 2011 Selection of the most stable reference gene is critical for a reliable interpretation of gene expression data using RT-PCR. In order so, 17 commonly used genes were analyzed in Wistar rat duodenum, jejunum, ileum and liver following a fat gavage and at two time periods.
Martínez-Beamonte, R. +8 more
openaire +3 more sources
α‐Synuclein aggregation landscape from phase separation to neurotoxic intermediates
FEBS Letters, EarlyView.Alpha‐synuclein aggregation in Parkinson's disease involves a complex landscape of transient intermediates, including oligomers, fibrils and liquid–liquid phase separation (LLPS). A view is emerging in which LLPS maturation into solid‐like condensates may contribute to the formation of neurotoxic species.
Silvia Arino +2 more
wiley +1 more source