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Advancing forensic-based investigation incorporating slime mould search for gene selection of high-dimensional genetic data. [PDF]
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Gene-culture coevolution under selection
Theoretical Population Biology, 2018The joint evolutionary dynamics of phenotypes and genotypes are usually couched in terms of genetic variance contributions to changes in the phenotypic mean. Here, we study the evolution of a dichotomous phenotype whose transmission is controlled by one multi-allelic locus. The phenotype is under selection, which may be genotype-dependent.
Hilla, Behar, Marcus W, Feldman
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Natural selection on gene expression
Trends in Genetics, 2006Changes in genetic regulation contribute to adaptations in natural populations and influence susceptibility to human diseases. Despite their potential phenotypic importance, the selective pressures acting on regulatory processes in general and gene expression levels in particular are largely unknown.
Yoav, Gilad +2 more
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Selective gene mutation in MEL cells
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1992MEL cells, undergoing erythroid differentiation and parasynchronized by dimethyl sulfoxide (DMSO) induction, were irradiated with a 3-s pulse of UV light at sublethal dose. A large number of clones deficient in different gene functions are found in the progeny of the treated cells, if the pulse irradiation is performed 18-24 h from the start of DMSO ...
FORESTI, MAGDA +2 more
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Gene selection for Brain Cancer Classification
2006 International Conference of the IEEE Engineering in Medicine and Biology Society, 2006With the introduction of microarray, cancer classification, diagnosis and prediction are made more accurate and effective. However, the final outcome of the data analyses very much depend on the huge number of genes with relatively small number of samples present in each experiment.
Hung, YS, Chang, CQ, Leung, YY, Fung, PC
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Gene Expression Data For Gene Selection Using Ensemble Based Feature Selection
2019 Ninth International Conference on Intelligent Computing and Information Systems (ICICIS), 2019The technology of next generation sequencing brought about evolution in research that based on sequence which replaces the microarray due to its advantages. The RNA-Seq is a high-throughput gene expression data that uses NGS technologies. The problem of high-throughput RNA-Seq datasets is the high of dimensionally (variables > observations) that need ...
Mohamad Aouf +5 more
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Natural Selection versus Gene Uniqueness
Nature, 1970SMITH1 has compared protein evolution with a popular word game. Just as the object of the game is to pass from one word to another by changing one letter at a time, so in the process of evolution one protein is changed to another by changing only one gene nucleotide at a time.
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Feature (Gene) Selection in Gene Expression-Based Tumor Classification
Molecular Genetics and Metabolism, 2001There is increasing interest in changing the emphasis of tumor classification from morphologic to molecular. Gene expression profiles may offer more information than morphology and provide an alternative to morphology-based tumor classification systems.
M, Xiong +4 more
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Selecting maximally informative genes
Computers & Chemical Engineering, 2005Microarray experiments are emerging as one of the main driving forces in modern biology. By allowing the simultaneous monitoring of the expression of the entire genome for a given organism, array experiments provide tremendous insight into the fundamental biological processes that translate genetic information.
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