Results 271 to 280 of about 1,213,334 (312)

A comparison of marker gene selection methods for single-cell RNA sequencing data. [PDF]

Genome Biol
Pullin JM, McCarthy DJ.
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source

Enhancing Cancerous Gene Selection and Classification for High-Dimensional Microarray Data Using a Novel Hybrid Filter and Differential Evolutionary Feature Selection. [PDF]

Cancers (Basel)
Hashmi A, Ali W, Abulfaraj A, Binzagr F, Alkayal E.   +4 more
europepmc   +1 more source

Genetic Algorithm Selection of Interacting Features (GASIF) for Selecting Biological Gene-Gene Interactions

Proceedings of the Genetic and Evolutionary Computation Conference
Rachit Kumar, David Zhang, Marylyn DeRiggi Ritchie   +2 more
openaire   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Establishment of an Efficient Sugarcane Transformation System via Herbicide-Resistant CP4-EPSPS Gene Selection. [PDF]

Plants (Basel)
Wang W, Javed T, Shen L, Sun T, Yang B, Zhang S.   +5 more
europepmc   +1 more source

Recent gene selection and drug resistance underscore clinical adaptation across Candida species. [PDF]

Nat Microbiol
Schikora-Tamarit MÀ, Gabaldón T.
europepmc   +1 more source

A Bayesian hierarchical hidden Markov model for clustering and gene selection: Application to kidney cancer gene expression data. [PDF]

Biom J
Chekouo T, Mukherjee H.
europepmc   +1 more source

Advancing forensic-based investigation incorporating slime mould search for gene selection of high-dimensional genetic data. [PDF]

Sci Rep
Qiu F, Heidari AA, Chen Y, Chen H, Liang G.   +4 more
europepmc   +1 more source