Results 101 to 110 of about 631,661 (355)

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

Molecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source

Multiple tumor suppressors regulate a HIF-dependent negative feedback loop via ISGF3 in human clear cell renal cancer. [PDF]

, 2018
Whereas VHL inactivation is a primary event in clear cell renal cell carcinoma (ccRCC), the precise mechanism(s) of how this interacts with the secondary mutations in tumor suppressor genes, including PBRM1, KDM5C/JARID1C, SETD2, and/or BAP1, remains ...
Cai, Weijia, Cai, Wesley L., Cho, Eun-Ah, Dulaimi, Essel, Jagannathan, Geetha, Jiang, Wei, Langbein, Lauren, Liao, Lili, Liu, Zongzhi Z., Na, Jie, Niu, Xiaohua, Peiper, Stephen C., Stark, George R., Sun, Jianxin, Testa, Joseph R., Uzzo, Robert G., Wang, Yuxin, Xu, Yaomin, Yan, Qin, Yang, Haifeng, Zhong, Zhijiu   +20 more
core   +1 more source

Finding regulatory modules through large-scale gene-expression data analysis

, 2004
The use of gene microchips has enabled a rapid accumulation of gene-expression data. One of the major challenges of analyzing this data is the diversity, in both size and signal strength, of the various modules in the gene regulatory networks of ...
Kloster, Morten, Tang, Chao, Wingreen, Ned   +2 more
core   +1 more source

Peripheral blood gene expression reveals an inflammatory transcriptomic signature in Friedreich's ataxia patients. [PDF]

, 2018
Transcriptional changes in Friedreich's ataxia (FRDA), a rare and debilitating recessive Mendelian neurodegenerative disorder, have been studied in affected but inaccessible tissues-such as dorsal root ganglia, sensory neurons and cerebellum-in animal ...
Coppola, Giovanni, Dokuru, Deepika, Farmer, Jennifer, Gao, Fuying, Isaacs, Charles, Lynch, David R, Nachun, Daniel, Perlman, Susan, Sears, Renee, Strawser, Cassandra, Van Berlo, Victoria, Yang, Zhongan   +11 more
core   +1 more source

Gene signatures of breast cancer progression and metastasis [PDF]

Breast Cancer Research, 2011
Breast cancer is a heterogeneous disease. Patient outcome varies significantly, depending on prognostic features of patients and their tumors, including patient age, menopausal status, tumor size and histology, nodal status, and so on. Response to treatment also depends on a series of predictive factors, such as hormone receptor and HER2 status ...
Ann F. Chambers, David I. Rodenhiser, Joseph Andrews, Theodore A. Vandenberg, Theodore A. Vandenberg   +4 more
openaire   +5 more sources

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

Gene Expression Signatures as Biomarkers of Tumour Hypoxia [PDF]

Clinical Oncology, 2015
Hypoxia is a feature of most solid tumours and is associated with a poor prognosis. The hypoxic environment can reduce the efficacy of radiotherapy and some chemotherapeutics, and has been investigated extensively as a therapeutic target. The clinical use of hypoxia-targeting treatment will benefit from the development of a biomarker to assess tumour ...
Harris, B, Barberis, Alessandro, West, Catharine, Buffa, Francesca M   +3 more
openaire   +4 more sources

Multi‐omic characterization of consensus molecular subtype 1 (CMS1) colorectal cancer with dampened immune response improves precision medicine

Molecular Oncology, EarlyView.
This study highlights the importance of multi‐omic analyses in characterizing colorectal cancers. Indeed, our analysis revealed a rare CMS1 exhibiting dampened immune activation, including reduced PD‐1 expression, moderate CD8+ T‐cell infiltration, and suppressed JAK/STAT pathway.
Livia Concetti, Manuel Scimeca, Julia Bischof, Jonathan Woodsmith, Massimiliano Agostini, Cristina Fiorani, Yufang Shi, Eleonora Candi, Gerry Melino, Alessandro Mauriello, Giuseppe S. Sica   +10 more
wiley   +1 more source

MRNA expression profiles of colorectal liver metastases as a novel biomarker for early recurrence after partial hepatectomy [PDF]

, 2016
Background: Identification of specific risk groups for recurrence after surgery for isolated colorectal liver metastases (CRLM) remains challenging due to the heterogeneity of the disease.
Ayez, N. (Ninos), Grunhagen, D.J. (Dirk Jan), Martens, J.W.M. (John), Sieuwerts, A.M. (Anieta), Sleijfer, S. (Stefan), Smid, M. (Marcel), Stok, E.P. van der, Verhoef, C. (Kees), Vermeulen, P.B. (Peter)   +8 more
core   +3 more sources

Maximizing biomarker discovery by minimizing gene signatures [PDF]

BMC Genomics, 2011
Abstract Background The use of gene signatures can potentially be of considerable value in the field of clinical diagnosis. However, gene signatures defined with different methods can be quite various even when applied the same disease and the same endpoint.
Chang Chang, Lajos Pusztai, Jennifer Fostel, Junwei Wang, Youping Deng, Chen Zhao, Weida Tong, Tieliu Shi, W. Fraser Symmans, Pierre R. Bushel   +9 more
openaire   +3 more sources