Results 171 to 180 of about 355,015 (248)

Lecithin Alleviates Memory Deficits and Muscle Attenuation in Chinese Older Adults and SAMP8 Mice

Advanced Science, EarlyView.
This study opens a new avenue for safeguarding cognition and muscle health, averting disability in older age, and treating age‐related pathologies through lecithin supplementation. It serves as a promising nonpharmacological intervention for the crosstalk of muscle and cognition.
Xianyun Wang, Dajun Li, Xiao Ying Li, Weizhao Lu, Huini Ding, Chengyan Qi, Xuan Wang, Jing Shen, Yafei Chi, Tiantian Li, Michelle M. Dunk, Yu An, Hongmei Huang, Kang Yu, Weili Xu, Rong Xiao, Yuandi Xi   +16 more
wiley   +1 more source

Establishment of a Virus-Induced Gene Silencing System in Abelmoschus manihot L. [PDF]

Plants (Basel)
Zhang T, Hou J, Chu H, Guo P, Sang Q, Liu Z, Cao L.   +6 more
europepmc   +1 more source

Molecular Determinants for Targeting Heterochromatin Protein 1-Mediated Gene Silencing: Direct Chromoshadow Domain–KAP-1 Corepressor Interaction Is Essential

, 2000
Mark S. Lechner, Gillian E. Begg, David W. Speicher, Frank J. Rauscher   +3 more
openalex   +1 more source

Exploring AAV‐Mediated Gene Therapy for Inner Ear Diseases: from Preclinical Success to Clinical Potential

Advanced Science, EarlyView.
Current preclinical studies of AAV‐mediated gene therapy explore different strategies based on the characteristics of inner ear diseases. For genetic hearing loss, approaches include the replacement of a “good gene,” removal of a “bad gene,” or direct correction of mutations through base editing.
Fan Wu, Wuhui He, Yun Xiao, Qiong Wu, Qing Zhang, Tiesong Zhang, Lei Xu, Xinyi Pang   +7 more
wiley   +1 more source

Host-induced gene silencing of Sporisorium scitamineum enhances resistance to smut in sugarcane. [PDF]

Plant Biotechnol J
Wu H, Qiu J, Zhang P, Lu S, Meng J, Huang X, Li R, Chen B.   +7 more
europepmc   +1 more source

The Trithorax-mimic Allele of Enhancer of zeste Renders Active Domains of Target Genes Accessible to Polycomb-Group-Dependent Silencing in Drosophila melanogaster [PDF]

, 2001
Izabella Bajusz, László Sípos, Zoltán Györgypál, Elizabeth A. Carrington, Richard S. Jones, János Gausz, Henrik Gyurkovics   +6 more
openalex   +1 more source

Glucose Deprivation‐Induced Disulfidptosis via the SLC7A11‐INF2 Axis: Pan‐Cancer Prognostic Exploration and Therapeutic Validation

Advanced Science, EarlyView.
Glucose deprivation or GLUT1 inhibition induces disulfidptosis in SLC7A11high ovarian cancer cells by promoting cystine accumulation, NADPH/ATP depletion, and F‐actin disulfide formation. SLC7A11 interacts with INF2 to further increase H₂O₂ levels and impair mitochondrial fission, suppressing cell migration. Targeting the SLC7A11–INF2 axis represents a
Zhenyu Song, Qiuming Yao, Lina Huang, Dan Cui, Jun Xie, Leilei Wu, Jianfeng Huang, Bo Zhai, Dan Liu, Xiao Xu   +9 more
wiley   +1 more source

Elucidating brain transport pathways and cell type-dependent gene silencing of a durable lipid-siRNA conjugate administered into cerebrospinal fluid. [PDF]

Nucleic Acids Res
Sorets AG, Schwensen KR, Francini N, Kjar A, Abdulrahman AM, Shostak A, Katdare KA, Schoch KM, Cowell RP, Park JC, Ligocki AP, Ford WT, Ventura-Antunes L, Hoogenboezem EN, Prusky A, Castleberry M, Michell DL, Fritsch E, Lyons SM, Miller TM, Vickers KC, Schrag MS, Duvall CL, Lippmann ES.   +23 more
europepmc   +1 more source

Technical Advance: Tobacco rattle virus as a vector for analysis of gene function by silencing [PDF]

, 2001
Frank Ratcliff, Ana Montserrat Martín‐Hernández, David C. Baulcombe   +2 more
openalex   +1 more source

Topoisomerase I Inhibition in ETV4‐overexpressed Non‐Small Cell Lung Cancer Promotes Replication and Transcription Mediated R‐Loop Accumulation and DNA Damage

Advanced Science, EarlyView.
The oncogenic ETS factor ETV4 exerts a pleiotropic control over DNA replication both in a transcription‐dependent and ‐independent fashion in NSCLC cells. High‐ETV4 expression leads to R‐loop formation and DNA damage in response to TOP1 inhibition.
Jiaxi Zhang, Yan Wang, Shanhu Cao, Shelly M. Xie, Bei Liu, Yimeng Li, Yuqi Hou, Xue Meng, Mingzhu Ruan, Di Bu, Jia Kang, Ruxin Li, Lei Lou, Juan Wang, Lingxiao Xing   +14 more
wiley   +1 more source