Results 11 to 20 of about 11,459,182 (339)
Journal of Law and the Biosciences, 2018 What, exactly, is "gene therapy"? Crystallizing a modern definition of "gene therapy" has now become critically important on several fronts. Following the recent of passage the 21st Century Cures Act, FDA now relies on the term to give regulatory incentives to sponsors of certain ‘regenerative medicines’, including ‘gene therapies’.
Jacob S. Sherkow +4 more
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Optimized riboswitch-regulated AAV vector for VEGF-B gene therapy
Frontiers in Medicine, 2022 Gene therapy would greatly benefit from a method to regulate therapeutic gene expression temporally. Riboswitches are small RNA elements that have been studied for their potential use in turning transgene expression on or off by ligand binding.
Reetta A. E. Eriksson +16 more
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Inflammatory Cytokines in Cancer: Comprehensive Understanding and Clinical Progress in Gene Therapy
Cells, 2021 The relationship between chronic inflammation and neoplastic diseases is not fully understood. The inflammatory microenvironment of a tumor is an intricate network that consists of numerous types of cells, cytokines, enzymes and signaling pathways ...
Tianxia Lan, Li Chen, Xiawei Wei
semanticscholar +1 more source
Proceedings of the National Academy of Sciences, 1997 In recent years, there have been a number of technological breakthroughs that have allowed for clinical trials in gene therapy to be initiated. In combination with the genome initiative, the potential for new therapeutics is limitless. Although an enormous amount of information has been obtained in a relatively short period of time, gene therapy ...
Mark A. Kay +2 more
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Cell & Bioscience, 2022 Background Bile acid (BA) homeostasis is mainly regulated by bile salt excretory pump (BSEP), a hepatocyte transporter that transfers BAs to the bile.
Javier Martínez-García +6 more
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The Current Status of Gene Therapy for the Treatment of Cancer
Biologics : targets & therapy, 2021 Gene therapy is the administration of foreign genomic material into the host tissue to modify the expression of a gene product or to change the biological properties of cells for therapeutic use.
T. M. Belete
semanticscholar +1 more source
Gene therapy in the anterior eye segment.
Current Gene Therapy, 2021 This review provides comprehensive information about the advances in gene therapy in the anterior segment of the eye including cornea, conjunctiva, lacrimal gland, and trabecular meshwork.
Cynthia Amador +4 more
semanticscholar +1 more source
Engineering Gene Therapy: Advances and Barriers
Advances in Therapy, 2021 Currently, 33 gene‐therapy drugs/products have been approved in the clinic. Over 3000 completed and ongoing clinical gene therapy trials have been reported worldwide. The development/maturation of tools for gene manipulation and gene delivery, as well as
Alireza Shahryari +3 more
semanticscholar +1 more source
Gene therapy on the move [PDF]
EMBO Molecular Medicine, 2013 The first gene therapy clinical trials were initiated more than two decades ago. In the early days, gene therapy shared the fate of many experimental medicine approaches and was impeded by the occurrence of severe side effects in a few treated patients.
Axel Schambach +5 more
openaire +5 more sources
Scientific Reports, 2023 Obesity and type 2 diabetes are two closely related diseases representing a serious threat worldwide. An increase in metabolic rate through enhancement of non-shivering thermogenesis in adipose tissue may represent a potential therapeutic strategy ...
Jordi Rodó +9 more
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