Results 211 to 220 of about 4,645,161 (307)

Targeting Gene Transcription Prevents Antibiotic Resistance. [PDF]

Antibiotics (Basel)
Agris PF.
europepmc   +1 more source

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source

A case displaying the importance of JAK1 and JAK2 gene transcription in antifungal defense against coccidioidomycosis. [PDF]

Front Med (Lausanne)
Priessnitz JK, Colore T, Nicolasora N.
europepmc   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

DREAM regulates insulin promoter activity through newly identified DRE element

Open Life Sciences, 2013
Daneva Teodora, Pashova Shina, Emilova Radoslava, Padeshki Plamen, Gagov Hristo, Georgiev Volodia   +5 more
doaj   +1 more source

CREB-Family Transcription Factors and Vasopressin-Mediated Regulation of Aqp2 Gene Transcription. [PDF]

J Am Soc Nephrol
Murillo-de-Ozores AR, Chen L, Ou SM, Park E, Khan S, Raghuram V, Yang CR, Chou CL, Knepper MA.   +8 more
europepmc   +1 more source

ATZ‐1 promotes DNA replication efficiency to maintain normal meiotic function

FEBS Open Bio, EarlyView.
Absence of ATZ‐1 interferes with meiotic DNA replication and cell cycle function via CHK‐1. This causes downstream defects associated with DNA damage and genomic integrity. Taken together, this study suggests that ATZ‐1 influences DNA replication efficiency and cell cycle function to maintain normal meiotic function.
Taylin E. Gourley, Luke W. Molesworth, Nethma H. Waduge, Fahimeh Eskandari, Peter R. Boag, Gregory M. Davis   +5 more
wiley   +1 more source

Non-coding RNAs and complex distributed genetic networks

Open Physics, 2011
Zhdanov Vladimir
doaj   +1 more source

Two compound heterozygous MEIOSIN (likely) pathogenic variants cause female infertility with premature ovarian insufficiency through the disruption of meiosis-related gene transcription. [PDF]

J Ovarian Res
Sha X, Zhang Y, Xia X, Ding H, Li Y, Li G, Hua R, Li K, Guo R, Du D, Xu Y, Cao Y, Wu H, Liu Y.   +13 more
europepmc   +1 more source

Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model

FEBS Open Bio, EarlyView.
This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito, Haduki Asano, Ayano Ueki, Joe Sakamoto, Yasuhiro Kamei, Hayato Tokumoto, Ayaka Yazawa, Shigeki Kamitani   +7 more
wiley   +1 more source