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Regulation of Immunoglobulin Gene Transcription
1992Analysis of the immunoglobulin gene suggests that their expression is controlled through the combinatorial action of tissue- and stage-specific factors (OTF-2, TF-microB, NF-kappa B), as well as more widely expressed E motif-binding factors such as E47/E12.
B, Nelsen, R, Sen
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1993
Abstract Understanding the mechanisms and control of gene transcription is one of the central goals for a large proportion of molecular biologists currently involved in research. This book concentrates on RNA polymerase II transcription of eukaryotic protein-coding systems. Many of the approaches and techniques described apply equally
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Abstract Understanding the mechanisms and control of gene transcription is one of the central goals for a large proportion of molecular biologists currently involved in research. This book concentrates on RNA polymerase II transcription of eukaryotic protein-coding systems. Many of the approaches and techniques described apply equally
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Transcriptional gene silencing mutants
Plant Molecular Biology, 2000Genetic approaches to identify molecular components of transcriptional gene silencing (TGS) in plants have yielded several Arabidopsis thaliana mutants and identified the first genes involved. All mutations found affect the maintenance of silencing and reactivate silent genes in trans.
Mittelsten Scheid, O., Paszkowski, Jerzy
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Gene transcription in HIV infection
Microbes and Infection, 2003Transcription from the HIV genome is regulated by the 5' long-terminal-repeat viral promoter as well as regulatory proteins, especially Tat and Rev. Both the promoter activity and the function of regulatory proteins require the activity of cellular components, thus the virus remains highly dependent on the metabolic state of the cell.
Yuntao, Wu, Jon W, Marsh
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Gene transcription in filamentous cyanobacteria
Microbiology, 1994Cyanobacteria are probably the most diverse group of prokaryotes in the number of species, type of habitats, morphology and physiological properties. Their common feature is 0,-evolving photosynthesis, performed by mechanisms similar to those of algae and higher plants.
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Transcriptional stochasticity in gene expression
Journal of Theoretical Biology, 2006Due to the small number of copies of molecular species involved, such as DNA, mRNA and regulatory proteins, gene expression is a stochastic phenomenon. In eukaryotic cells, the stochastic effects primarily originate in regulation of gene activity. Transcription can be initiated by a single transcription factor binding to a specific regulatory site in ...
Lipniacki, Tomasz +4 more
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Regulation of insulin gene transcription
Seminars in Cell & Developmental Biology, 2000Recent studies of the insulin gene promoter and the transcription factors that regulate it have expanded our understanding of both how the production of insulin is restricted to the pancreatic beta -cell, and how that production is regulated by physiologic signals such as glucose. A picture is emerging in which an elaborate set of transcription factors
K, Ohneda, H, Ee, M, German
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Transcriptional regulation of the survivin gene
Molecular Biology Reports, 2013Survivin, a small member of the inhibitors of the apoptosis protein family, is highly deregulated in cancer. It is weakly expressed in normal tissues but very strongly expressed in malignant lesions. Survivin is involved in cell-cycle progression, especially in the G2/M transition, and has anti-apoptotic activity, which correlates with its strong ...
Romain, Boidot +2 more
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On the ontogeny of cardiac gene transcripts
Mechanisms of Ageing and Development, 1994As a prerequisite to investigating the specification and differentiation of cardiac tissue in vitro, the ontogeny of a number of putative cardiac-specific, and striated muscle-specific gene transcripts has been studied. The probes used include cDNAs of alpha-actins, myosin heavy chains, myosin light chains, alpha-tropomyosin, troponin-T and atrial ...
W G, Murrell +3 more
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Fusion genes and transcripts in neoplasia
Molecular Biology, 2011Chromosomal rearrangements resulting in the formation of fusion genes are common events in carcinogenesis. There are more than 440 known fusion genes found in both malignant and benign tumors. The mechanism of transcription induced chimerism (TIC) contributes to fusion transcripts in normal human tissues.
T V, Kekeeva +3 more
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