Results 241 to 250 of about 4,645,161 (307)

<i>proRate</i>: an R package to infer gene transcription rates with a novel least sum of squares method. [PDF]

NAR Genom Bioinform
Liu Y, Alakwaa F.
europepmc   +1 more source

Cell surface CD11c as a neutrophil aging marker molecule

FEBS Open Bio, EarlyView.
Cell surface CD11chi neutrophils were more aged and had better phagocytic function than CD11c−/lo neutrophils. Transcriptomic analysis of CD11chi neutrophils and CD11c−/lo neutrophils in pediatric population showed that the most difference was seen in infants.
Sophia Koutsogiannaki, Fahd Alhamdan, Erik Malm, Marie Bermudez, Samuel Y. Kim, Koichi Yuki   +5 more
wiley   +1 more source

Changes in cultivation parameters impact cytochrome P450 gene transcription in HepaRG cells: implications for <i>in vitro</i> toxicological assessments. [PDF]

Front Pharmacol
Jochum K, Städele V, Marx-Stoelting P.
europepmc   +1 more source

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

FEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source

The Kaposi's sarcoma-associated herpesvirus TBP mimic uses a noncanonical DNA-binding mode to promote viral late gene transcription. [PDF]

Nucleic Acids Res
Llacsahuanga-Allcca LE, Didychuk AL, Rodríguez-Vargas A, Glaunsinger BA.   +3 more
europepmc   +1 more source

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

FEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen, Duc Trung Nguyen, Minyoung Cho, Jihun Kim, Soyeon In, Thai Uy Nguyen, Sunghoon Hurh, Beom Jin Park, Jong‐Ik Hwang   +8 more
wiley   +1 more source

Novel drug-inducible CRISPRa/i systems for rapid and reversible manipulation of gene transcription. [PDF]

Cell Mol Life Sci
Sui M, Zhou M, Cui M, Liu H, Zhang X, Hu N, Li Y, Wang B, Yang G, Gui P, Zhu L, Wan F, Zhang B.   +12 more
europepmc   +1 more source

Peripheral immune progression to long COVID is associated with mitochondrial gene transcription: A meta-analysis. [PDF]

Mitochondrion
Maison DP, Khadka VS, Mohd-Ibrahim I, Peluso MJ, Henrich TJ, Deng Y, Gerschenson M.   +6 more
europepmc   +1 more source

Starvation activates ECM-remodeling gene transcription and putative enhancers in fibroblasts despite inducing quiescence. [PDF]

Cell Rep
Secchia S, Beilinson V, Chen X, Gucwa M, Denson LA, Miraldi ER, Weirauch MT, Ikegami K.   +7 more
europepmc   +1 more source

Chromatin conformation, gene transcription, and nucleosome remodeling as an emergent system. [PDF]

Sci Adv
Almassalha LM, Carignano M, Liwag EP, Li WS, Gong R, Acosta N, Dunton CL, Gonzalez PC, Carter LM, Kakkaramadam R, Kröger M, MacQuarrie KL, Frederick J, Ye IC, Su P, Kuo T, Medina KI, Pritchard JA, Skol A, Nap R, Kanemaki M, Dravid V, Szleifer I, Backman V.   +23 more
europepmc   +1 more source