Results 111 to 120 of about 10,802,441 (400)
Disruption of SETD3‐mediated histidine‐73 methylation by the BWCFF‐associated β‐actin G74S mutation
FEBS Letters, EarlyView.The β‐actin G74S mutation causes altered interaction of actin with SETD3, reducing histidine‐73 methylation efficiency and forming two distinct actin variants. The variable ratio of these variants across cell types and developmental stages contributes to tissue‐specific phenotypical changes. This imbalance may impair actin dynamics and mechanosensitive
Anja Marquardt +8 more
wiley +1 more source
Cellular and Molecular Barriers to Gene Transfer by a Cationic Lipid (*)
Journal of Biological Chemistry, 1995 Cationic lipids are widely used for gene transfer in vitro and show promise as a vector for in vivo gene therapy applications. However, there is limited understanding of the cellular and molecular mechanisms involved. We investigated the individual steps
J. Zabner +4 more
semanticscholar +1 more source
Organic farming and gene transfer from genetically modified crops [PDF]
, 1999 This is the final report of MAFF/Defra project OF0157. Genetically modified (GM) crops cannot be released into the environment and used as food, feed, medicines or industrial processing before they have passed through a rigorous and internationally ...
Dale, Philip J., Moyes, Catherine L.
core
FEBS Letters, EarlyView.This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao +7 more
wiley +1 more source
tRNAscan-SE On-line: integrating search and context for analysis of transfer RNA genes
Nucleic Acids Res., 2016 High-throughput genome sequencing continues to grow the need for rapid, accurate genome annotation and tRNA genes constitute the largest family of essential, ever-present non-coding RNA genes. Newly developed tRNAscan-SE 2.0 has advanced the state-of-the-
T. Lowe, Patricia P. Chan
semanticscholar +1 more source
, 2014 Pathogenic bacteria present a large disease burden on human health. Control of these pathogens is hampered by rampant lateral gene transfer, whereby pathogenic strains may acquire genes conferring resistance to common antibiotics. Here we introduce tools
A. Holzinger +13 more
core +1 more source
Molecular Therapy: Methods & Clinical Development, 2022 Wilson’s disease (WD) is an inherited disorder of copper metabolism associated with mutations in ATP7B gene. We have shown that the administration of an adeno-associated vector (AAV) encoding a mini version of human ATP7B (VTX-801) provides long-term ...
Oihana Murillo +13 more
doaj
Phase Diagrams of Quasispecies Theory with Recombination and Horizontal Gene Transfer
, 2006 We consider how transfer of genetic information between individuals influences the phase diagram and mean fitness of both the Eigen and the parallel, or Crow-Kimura, models of evolution.
J. Maynard +4 more
core +1 more source
tRNAscan-SE 2.0: improved detection and functional classification of transfer RNA genes
bioRxiv, 2019 tRNAscan-SE has been widely used for transfer RNA (tRNA) gene prediction for over twenty years, developed just as the first genomes were decoded. With the massive increase in quantity and phylogenetic diversity of genomes, the accurate detection and ...
Patricia P. Chan +3 more
semanticscholar +1 more source
FEBS Letters, EarlyView.In the adult T‐cell leukemia/lymphoma (ATL) cell line ED, the human T‐cell leukemia virus type 1 (HTLV‐1) provirus was integrated into the intron of the ift81 gene in the antisense orientation. Despite this integration, both the intact ift81 and the viral oncogene hbz were simultaneously expressed, likely due to the functional insufficiency of viral ...
Mayuko Yagi +5 more
wiley +1 more source