Results 121 to 130 of about 11,371,695 (398)

Bacterial gene transfer by natural genetic transformation in the environment.

Microbiological reviews, 1994
Natural genetic transformation is the active uptake of free DNA by bacterial cells and the heritable incorporation of its genetic information. Since the famous discovery of transformation in Streptococcus pneumoniae by Griffith in 1928 and the ...
M. G. Lorenz, W. Wackernagel
semanticscholar   +1 more source

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source

tRNAscan-SE On-line: integrating search and context for analysis of transfer RNA genes

Nucleic Acids Res., 2016
High-throughput genome sequencing continues to grow the need for rapid, accurate genome annotation and tRNA genes constitute the largest family of essential, ever-present non-coding RNA genes. Newly developed tRNAscan-SE 2.0 has advanced the state-of-the-
T. Lowe, Patricia P. Chan
semanticscholar   +1 more source

Horizontal gene transfer in the innovation and adaptation of land plants [PDF]

, 2013
Jipei Yue, Xiangyang Hu, Jinling Huang
openalex   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Origin and evolution of antibiotic resistance: the common mechanisms of emergence and spread in water bodies

Frontiers in Microbiology, 2012
The environment, and especially fresh water, constitutes a reactor where the evolution and the rise of new resistances occur. In rivers or streams, bacteria from different sources such as urban, industrial and agricultural waste, probably selected by ...
Agnese eLupo, Sebastien eCoyne, Thomas Ulrich Berendonk   +2 more
doaj   +1 more source

Eukaryote to gut bacteria transfer of a glycoside hydrolase gene essential for starch breakdown in plants [PDF]

, 2012
Maria Cecilia Arias, Étienne Danchin, Pedro M. Coutinho, Bernard Henrissat, Steven Ball   +4 more
openalex   +1 more source

The largest reservoir of mitochondrial introns is a relic of an ancestral split gene [PDF]

, 2010
In eukaryotes, introns are located in nuclear and organelle genes from several kingdoms (ref. 1-4). Large introns (0.1 to 5 kbp) are frequent in mitochondrial genomes of plant and fungi (ref.
Cyril Ferandon, Gerard Barroso, Jean-Pierre Benedetto, Michel Castroviejo, Philippe Callac, Serge Moukha   +5 more
core   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Passive Immunization against HIV/AIDS by Antibody Gene Transfer [PDF]

, 2014
Lili Yang, Pin Wang
openalex   +1 more source