Results 131 to 140 of about 11,371,695 (398)
Molecular Oncology, EarlyView.PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham +21 more
wiley +1 more source
Novel T cells with improved in vivo anti-tumor activity generated by RNA electroporation
Protein & Cell, 2017 The generation of T cells with maximal anti-tumor activities will significantly impact the field of T-cell-based adoptive immunotherapy. In this report, we found that OKT3/IL-2-stimulated T cells were phenotypically more heterogeneous, with enhanced anti-
Xiaojun Liu +7 more
doaj +1 more source
Stigmergic gene transfer and emergence of universal coding [PDF]
, 2009 Mikhail Prokopenko +2 more
openalex +1 more source
Molecular Oncology, EarlyView.This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan +9 more
wiley +1 more source
Antibiotic resistance via the food chain: Fact or fiction?
South African Journal of Science, 2010 The mechanisms that bacteria use to acquire additional genetic material, including genes coding for antibiotic resistance, are principally the secondary pathways that have been described as transformation and conjugation pathways.
Linda Bester, Sabiha Essack
doaj
Herpes Simplex Virus Vectors for Gene Transfer to the Central Nervous System
Diseases, 2018 Neurodegenerative diseases (NDs) have a profound impact on human health worldwide and their incidence is predicted to increase as the population ages. ND severely limits the quality of life and leads to early death.
Sara Artusi +4 more
doaj +1 more source
Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology
Molecular Oncology, EarlyView.Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts +8 more
wiley +1 more source
Consistency of orthology and paralogy constraints in the presence of gene transfers [PDF]
, 2017 Mark Jones +2 more
openalex +1 more source
Molecular Oncology, EarlyView.A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira +14 more
wiley +1 more source
Mikrobielle Vielfalt in der Rhizosphäre und im Boden
Julius-Kühn-Archiv, 2013 Soil microbes are of enormous importance for functioning nutrient cycles as well as for plant health. The development and application of nucleic acid based techniques provided new insights into the diversity of bulk and rhizosphere soil microbes.
Smalla, Kornelia, Heuer, Holger
doaj +1 more source