Results 161 to 170 of about 5,395,678 (315)

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Advances in gene transfer technologies: comparing viral and non-viral vectors for therapeutic applications. [PDF]

3 Biotech
Halagali P, Seenivasan R, Sreedevi A, Ligade VS, Bugadannavar P, Sharma H, Rai SN, Tippavajhala VK.   +7 more
europepmc   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Distribution of poly(A) polymerase I in bacteria: an expanded role for horizontal gene transfer. [PDF]

Microbiology (Reading)
Jones GH.
europepmc   +1 more source

Neuroimaging Applications for the Delivery and Monitoring of Gene Therapy for Central Nervous System Diseases

Neurological disease due to single gene defects represents a targetable entity for adeno-associated virus (AAV) mediated gene therapy. The delivery of AAV-mediated gene therapy to the brain is challenging, owing to the presence of the blood-brain barrier.
Vardar, Zeynep, Gray-Edwards, Heather L, Daci, Rrita, Flotte, Terence R, Shazeeb, Mohammed Salman, Cataltepe, Oguz I, Vachha, Behroze   +6 more
core   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Horizontal Gene Transfer and Genome Rearrangements Shape Bacterial Adaptation for Bioremediation. [PDF]

Environ Microbiol
Saati-Santamaría Z, Flores A, Canosa I, García-Fraile P.   +3 more
europepmc   +1 more source

Transfer of the Insecticidal Crystal Protein Gene of Bacillus thuringiensis into Cabbage (Brassica oleracea L. var. capitata L.)

, 2014
本試驗將攜帶有 Cauliflower Mosaic Virus 35S(CaMV 35S)及rubisco small subunit(rbcS)啟動子的轉殖載體，以蘇力菌殺蟲晶體蛋白基因(crylA(b))，利用農桿菌基因轉移法將其轉移到甘藍(新豐、初秋)的子葉或下胚軸。本實驗之目的在建立甘藍基因轉移及植株再生系統，研究不同啟動子對表現此基因的影響，並探討培育成抗蟲之蔬菜的可行性。The research focuses on the use of cruciferous vegetables as
Lung-Wu Chang, Menq-Jiau Tseng, 曾夢蛟, 張隆武   +3 more
core  

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Signatures of gene transfer in the parallel evolution of osmotrophic specialization in eukaryotes. [PDF]

Nat Ecol Evol
Ocaña-Pallarès E, Richards TA, Gabaldón T, Szöllősi GJ.   +3 more
europepmc   +1 more source